Azetukalner, a Novel KV7 Potassium Channel Opener, in Adults With Major Depressive Disorder
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.14278
Abstract: This randomized clinical trial assesses the efficacy and safety of azetukalner, a novel, KV7 potassium channel opener, in participants with MDD. read more here.
Keywords: kv7 potassium; channel opener; novel kv7; potassium channel ... See more keywords
Abstract 4369129: Essential Role of KCNQ5 (Kv7.5) Potassium Channels in Vascular Reactivity and Adrenergic Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4369129
Abstract: Introduction/Background: Vascular tone dysregulation is central to cardiovascular pathophysiology. KCNQ (Kv7) potassium channels, primarily heteromeric KCNQ4/5 channels, regulate smooth muscle membrane potential and contractility, yet the specific role of the KCNQ5 subunit in vascular reactivity… read more here.
Keywords: kcnq5; role; kv7 potassium; vascular reactivity ... See more keywords