Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3224
Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.
Keywords: kynurenine; age; bone; kyn ... See more keywords
Urinary kynurenine as a biomarker for Parkinson’s disease
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DOI: 10.1007/s10072-020-04589-x
Abstract: Objective To examine whether urine kynurenine (KYN) levels were associated with early-stage Parkinson’s disease (PD), as well as the value of urine KYN as a potential biomarker in early-stage PD. Method Eighty-two participants including 41… read more here.
Keywords: urine kyn; biomarker; kyn levels; kyn ... See more keywords
Promoting epithelial-to-mesenchymal transition by d-kynurenine via activating aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3323-y
Abstract: Epithelial-to-mesenchymal transition (EMT) is believed to play key roles in the process of cancer metastasis. The molecular changes during EMT are characterized by the down-regulation of epithelial proteins, such as E-cadherin, and the up-regulation of… read more here.
Keywords: kynurenine; mesenchymal transition; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior.
Sign Up to like & getrecommendations! Published in 2019 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2019.101894
Abstract: BACKGROUND Depression is a wide-spread disease that affects millions of people worldwide. Recent studies in neuroinflammation suggested that increased plasma kynurenine (KYN) level was related to depressive symptoms, while animal studies indicated that KYN increase… read more here.
Keywords: exercise prevents; like behavior; kyn; exercise ... See more keywords
Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells
Sign Up to like & getrecommendations! Published in 2020 at "Bone Reports"
DOI: 10.1016/j.bonr.2020.100270
Abstract: Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here,… read more here.
Keywords: age related; age; bone; mir29b ... See more keywords
Abstract 4361: Kynurenine - Aryl hydrocarbon receptor axis: A crucial modulator of immunometabolism in cisplatin resistant lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4361
Abstract: The effect of tumor metabolism on the tumor microenvironment is not well established. Our previous data have shown that cisplatin resistant (CR) lung cancer cells increased secretion of thioredoxin-1 (TRX1) and kynurenine (KYN). Interestingly, high… read more here.
Keywords: kyn; resistant lung; cancer; cisplatin resistant ... See more keywords
Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Perinatal Medicine"
DOI: 10.1515/jpm-2022-0446
Abstract: Abstract Objectives Kynurinine (KYN) and its metabolites, which are released during the metabolism of tryptophan, an essential amino acid, have many important functions, such as cellular energy production, regulation of vascular tone, and regulation of… read more here.
Keywords: kyn; growth restriction; serum kyn; fgr oligohydramnios ... See more keywords
Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.950441
Abstract: Objective The occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention. This study aimed to evaluate… read more here.
Keywords: kyn could; kyn; myocardial infarction; stemi patients ... See more keywords
The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis
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DOI: 10.3389/fnut.2021.712327
Abstract: Background: The incidence of renal cell carcinoma (RCC) is increasing year by year. It is difficult to have complete treatment so far. Studies have shown that tryptophan metabolite Kynurenine (Kyn) affects cell proliferation, migration, apoptosis,… read more here.
Keywords: 786 cells; metabolite kyn; tryptophan metabolite; kyn ... See more keywords
Increasing plasma L-kynurenine impairs mitochondrial oxidative phosphorylation prior to the development of atrophy in murine skeletal muscle: A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.992413
Abstract: Introduction: L-Kynurenine (L-Kyn), a product of tryptophan (Trp) catabolism, has been linked with impairments in walking speed, muscle strength/size, and physical function. The purpose of this pilot study was to develop a dietary model that… read more here.
Keywords: kyn; oxidative phosphorylation; plasma kyn; muscle ... See more keywords
High Kynurenine (a Tryptophan Metabolite) Predicts Remission in Patients with Major Depression to Add-on Treatment with Celecoxib
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2017.00016
Abstract: Background Signs of an inflammatory process have been described in major depression. Methods In a double-blind, randomized study of celecoxib or placebo add-on to reboxetine in 40 depressed patients, celecoxib treatment has beneficial effects. In… read more here.
Keywords: treatment celecoxib; treatment; remission; major depression ... See more keywords