Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3224
Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.
Keywords: kynurenine; age; bone; kyn ... See more keywords
Blueberry extract for the treatment of ischaemic stroke through regulating the gut microbiota and kynurenine metabolism
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8300
Abstract: Although the gut microbiota and kynurenine (KYN) metabolism have significant protective effects against ischaemic stroke (IS), the exact mechanism has yet to be fully elucidated. Combined serum metabolomics and 16S rRNA gene sequencing were used… read more here.
Keywords: gut microbiota; microbiota kynurenine; metabolism; kyn ... See more keywords
Urinary kynurenine as a biomarker for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurological Sciences"
DOI: 10.1007/s10072-020-04589-x
Abstract: Objective To examine whether urine kynurenine (KYN) levels were associated with early-stage Parkinson’s disease (PD), as well as the value of urine KYN as a potential biomarker in early-stage PD. Method Eighty-two participants including 41… read more here.
Keywords: urine kyn; biomarker; kyn levels; kyn ... See more keywords
Promoting epithelial-to-mesenchymal transition by d-kynurenine via activating aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3323-y
Abstract: Epithelial-to-mesenchymal transition (EMT) is believed to play key roles in the process of cancer metastasis. The molecular changes during EMT are characterized by the down-regulation of epithelial proteins, such as E-cadherin, and the up-regulation of… read more here.
Keywords: kynurenine; mesenchymal transition; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Physical exercise prevents mice from L-Kynurenine-induced depression-like behavior.
Sign Up to like & getrecommendations! Published in 2019 at "Asian journal of psychiatry"
DOI: 10.1016/j.ajp.2019.101894
Abstract: BACKGROUND Depression is a wide-spread disease that affects millions of people worldwide. Recent studies in neuroinflammation suggested that increased plasma kynurenine (KYN) level was related to depressive symptoms, while animal studies indicated that KYN increase… read more here.
Keywords: exercise prevents; like behavior; kyn; exercise ... See more keywords
Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells
Sign Up to like & getrecommendations! Published in 2020 at "Bone Reports"
DOI: 10.1016/j.bonr.2020.100270
Abstract: Mechanisms leading to age-related reductions in bone formation and subsequent osteoporosis are still incompletely understood. We recently demonstrated that kynurenine (KYN), a tryptophan metabolite, accumulates in serum of aged mice and induces bone loss. Here,… read more here.
Keywords: age related; age; bone; mir29b ... See more keywords
Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101)
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00700
Abstract: 4-Chlorokynurenine (4-Cl-KYN, AV-101) is a prodrug of a NMDA receptor antagonist and is in clinical development for potential CNS indications. We sought to further understand the distribution and metabolism of 4-Cl-KYN, as this information might… read more here.
Keywords: acetyl kyn; distribution; chlorokynurenine; drug ... See more keywords
Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2025 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.4c00586
Abstract: The tryptophan (TRP) metabolic pathway produces kynurenine (KYN) and serotonin (5-HT). These are important molecules in the central nervous system, as KYN plays a crucial role in neuroprotection, while 5-HT impacts mood and sleep patterns.… read more here.
Keywords: brain; resolution mass; administration; kyn ... See more keywords
Abstract 4361: Kynurenine - Aryl hydrocarbon receptor axis: A crucial modulator of immunometabolism in cisplatin resistant lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4361
Abstract: The effect of tumor metabolism on the tumor microenvironment is not well established. Our previous data have shown that cisplatin resistant (CR) lung cancer cells increased secretion of thioredoxin-1 (TRX1) and kynurenine (KYN). Interestingly, high… read more here.
Keywords: kyn; resistant lung; cancer; cisplatin resistant ... See more keywords
Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Perinatal Medicine"
DOI: 10.1515/jpm-2022-0446
Abstract: Abstract Objectives Kynurinine (KYN) and its metabolites, which are released during the metabolism of tryptophan, an essential amino acid, have many important functions, such as cellular energy production, regulation of vascular tone, and regulation of… read more here.
Keywords: kyn; growth restriction; serum kyn; fgr oligohydramnios ... See more keywords
Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.950441
Abstract: Objective The occurrence of cardiovascular adverse events in the first year after ST-acute myocardial infarction (STEMI) remains high; therefore, identification of patients with poor prognosis is essential for early intervention. This study aimed to evaluate… read more here.
Keywords: kyn could; kyn; myocardial infarction; stemi patients ... See more keywords