Impaired metabolism of kynurenine and its metabolites in CSF of parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134576
Abstract: AIM The kynurenine (KYN) pathway plays an important role in degrading molecules responsible for oxidative stress in the central nervous system (CNS), but can also have neurotoxic effects. Both 3-hydroxykynurenine (3-HK) and quinolinic acid are… read more here.
Keywords: kynurenine; kyn pathway; csf levels; parkinson disease ... See more keywords
The Kynurenine Pathway and Bipolar Disorder: Intersection of the Monoaminergic and Glutamatergic Systems and Immune Response
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-019-0589-8
Abstract: Dysfunction in a wide array of systems—including the immune, monoaminergic, and glutamatergic systems—is implicated in the pathophysiology of depression. One potential intersection point for these three systems is the kynurenine (KYN) pathway. This study explored… read more here.
Keywords: post ketamine; monoaminergic glutamatergic; glutamatergic systems; kyn pathway ... See more keywords
Changes in Kynurenine Pathway Metabolites After Acute Psychosocial Stress in Healthy Males: A Single-Arm Pilot Study.
Sign Up to like & getrecommendations! Published in 2021 at "Stress"
DOI: 10.1080/10253890.2021.1959546
Abstract: Chronic stress is associated with an increased conversion of tryptophan (TRP) into kynurenine (KYN). However, only a few studies investigated KYN pathway metabolite concentrations following acute stress in healthy subjects. We hypothesized that TRP/KYN metabolism… read more here.
Keywords: stress induction; pathway metabolites; trp; kyn pathway ... See more keywords
Targeting Tryptophan Catabolic Kynurenine Pathway Enhances Anti-Tumor Immunity and Cytotoxicity in Multiple Myeloma
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DOI: 10.1182/blood-2018-99-117827
Abstract: Introduction. Plasmacytoid dendritic cells (pDCs) play an integral role in MM pathogenesis (Chauhan et al, Cancer Cell 2009, 16:309-323). pDCs interactions with tumor cells and T/NK effector cells in the MM-BM milieu induce immune suppression… read more here.
Keywords: immunity; kyn pathway; pdc; pathway ... See more keywords
Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
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DOI: 10.3390/biomedicines9070734
Abstract: The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a… read more here.
Keywords: trp kyn; metabolic pathway; disorder; kyn pathway ... See more keywords
Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15020256
Abstract: Accumulating evidence suggests an association of the tryptophan–kynurenine (TRP-KYN) pathway with atherosclerosis and cardiovascular risk factors. In this cross-sectional analysis we investigated whether TRP-KYN pathway parameters are associated with 24 h blood pressure (BP) and… read more here.
Keywords: trp kyn; risk factors; cardiovascular risk; kyn pathway ... See more keywords