Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30587
Abstract: Kynureninase (KYNU) is a key enzyme in the tryptophan metabolism pathway with elevated expression in psoriatic lesions relative to normal skin. However, whether KYNU contributes to the pathogenesis of psoriasis remains unknown. We sought to… read more here.
Keywords: kynureninase; kynu; skin; psoriasis ... See more keywords
Abstract 6031: KYNU upregulation is a prominent feature of NRF2-activated cancers and is associated with tumor immunosuppression and poor prognosis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6031
Abstract: Activation of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, either through gain-of-function mutations in the NRF2 encoding gene NFE2L2 or through loss-of-function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1), is a frequent… read more here.
Keywords: expression; kynu upregulation; kynu; gene ... See more keywords
Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
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DOI: 10.3390/cancers15030834
Abstract: Simple Summary We previously reported a novel mechanism of NRF2 tumoral immune suppression through selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the current study, we report that elevated tumoral KYNU… read more here.
Keywords: tumor; expression; kynu; gene ... See more keywords
High KYNU Expression Is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas
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DOI: 10.3390/cancers17101681
Abstract: Simple Summary Lung adenocarcinoma is a common and deadly form of lung cancer, and better tools are needed to predict how aggressive the disease will be and which treatments may work best. In this study,… read more here.
Keywords: poor prognosis; kynu; lung; high kynu ... See more keywords