Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
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DOI: 10.1002/jcp.30587
Abstract: Kynureninase (KYNU) is a key enzyme in the tryptophan metabolism pathway with elevated expression in psoriatic lesions relative to normal skin. However, whether KYNU contributes to the pathogenesis of psoriasis remains unknown. We sought to… read more here.
Keywords: kynureninase; kynu; skin; psoriasis ... See more keywords
Abstract 6031: KYNU upregulation is a prominent feature of NRF2-activated cancers and is associated with tumor immunosuppression and poor prognosis
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DOI: 10.1158/1538-7445.am2023-6031
Abstract: Activation of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, either through gain-of-function mutations in the NRF2 encoding gene NFE2L2 or through loss-of-function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1), is a frequent… read more here.
Keywords: expression; kynu upregulation; kynu; gene ... See more keywords
Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
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DOI: 10.3390/cancers15030834
Abstract: Simple Summary We previously reported a novel mechanism of NRF2 tumoral immune suppression through selective upregulation of the tryptophan-metabolizing enzyme kynureninase (KYNU) in lung adenocarcinoma. In the current study, we report that elevated tumoral KYNU… read more here.
Keywords: tumor; expression; kynu; gene ... See more keywords