Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.02.009
Abstract: Psychological stress is well known to increase colitis susceptibility and promote relapse. Metabolic changes are commonly observed under psychological stress, but little is known how this relates to the progression of colitis. Here we show… read more here.
Keywords: social stress; kynurenic acid; inflammasome activation; stress ... See more keywords
Tryptophan circuit in fatigue: From blood to brain and cognition
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.09.002
Abstract: Brain tryptophan and its neuroactive metabolites play key roles in central fatigue. However, previous brain function analysis targets may have included both glia and neurons together. Here, we clarified the fatigue-cognitive circuit of the central-peripheral… read more here.
Keywords: kynurenic acid; fatigue; tryptophan; circuit ... See more keywords
Experimental hypothyroidism raises brain kynurenic acid - Novel aspect of thyroid dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173363
Abstract: Hypothyroidism frequently manifests with altered mood and disturbed cognition. Kynurenic acid may influence cognition through antagonism of N-methyl-d-aspartate receptors (NMDA) and α7 nicotinic receptors. In here, thyroid hormones effects on kynurenic acid synthesis in rat… read more here.
Keywords: hypothyroidism; kynurenic acid; brain kynurenic; acid ... See more keywords
Acute liver failure increases kynurenic acid production in rat brain via changes in tryptophan metabolism in the periphery
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.02.004
Abstract: The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor and N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Recent studies have suggested that increased brain KYNA levels are involved… read more here.
Keywords: tryptophan metabolism; kyna; kynurenic acid; brain ... See more keywords
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity
Sign Up to like & getrecommendations! Published in 2017 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2016.11.017
Abstract: Increased cytokines and kynurenic acid (KYNA) levels in cerebrospinal fluid (CSF) have been reported in patients with schizophrenia and bipolar disorder. The aim of the present study was to investigate cytokines and kynurenines in the… read more here.
Keywords: kynurenic acid; personality traits; csf; personality ... See more keywords
Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0038-4
Abstract: Abnormalities in the kynurenine pathway (KP) of tryptophan degradation, leading to the dysfunction of neuroactive KP metabolites in the brain, have been implicated in the pathophysiology of schizophrenia (SZ). One plausible mechanism involves dysregulation of… read more here.
Keywords: kynurenic acid; schizophrenia; plasma; kynurenine kynurenic ... See more keywords
Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-017-0006-2
Abstract: Mesenchymal stem cells (MSCs) have been demonstrated to be anti-inflammatory against various immune disorders through several factors, including indoleamine 2,3-dioxygenase (IDO) and TNF-stimulated gene 6 (TSG-6). However, little is known about the necessity for both… read more here.
Keywords: kynurenic acid; ido; controls tsg; tsg ... See more keywords
Kynurenic acid as the neglected ingredient of commercial baby formulas
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42646-4
Abstract: The global increase in resorting to artificial nutritional formulas replacing breastfeeding has been identified among the complex causes of the obesity epidemic in infants and children. One of the factors recently recognized to influence metabolism… read more here.
Keywords: milk; kynurenic acid; kyna; gain ... See more keywords
Kynurenic acid may underlie sex-specific immune responses to COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abf8483
Abstract: Compared to females, male COVID-19 patients have more kynurenic acid, which may underlie their poorer immune response. Sex-specific metabolism and COVID-19 Males and females have different immune responses to SARS-CoV-2 infection, with male sex being… read more here.
Keywords: covid patients; kynurenic acid; immune responses; sex specific ... See more keywords
Dysregulation of Tryptophan Metabolism and Distortion of Cell Signaling after Oral Exposure to Ethanol and Kynurenic Acid.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.2139/ssrn.4109815
Abstract: Kynurenic acid (KYNA), an unavoidable tryptophan metabolite during fermentation is naturally blended with alcohol in all alcoholic beverages. Thus, alcohol drinking inevitably results in co-intake of KYNA. Effects of alcohol or KYNA on human health… read more here.
Keywords: tryptophan metabolism; alcohol kyna; kynurenic acid; cell signaling ... See more keywords
Reactions of kynurenic acid with hypobromous acid and hypochlorous acid
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.20-62
Abstract: Kynurenic acid, a tryptophan metabolite, acts as antagonist or agonist of several receptors. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. At inflammation sites, kynurenic acid may encounter HOBr and… read more here.
Keywords: bromokynurenic acid; kynurenic acid; hypobromous acid; product ... See more keywords