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   Articles with "kynurenine" as a keyword



An exploratory study on the effect of kynurenine metabolites on sEnd‐2 endothelioma cells

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recommendations! Published in 2024 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.4065

Abstract: Cancer is the second leading cause of mortality worldwide. The development of anticancer therapy plays a crucial role in mitigating tumour progression and metastasis. Epithelioid hemangioendothelioma is a very rare cancer, however, with a high… read more here.

Keywords: effect; kynurenine; cell; kynurenine metabolites ... See more keywords

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

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recommendations! Published in 2017 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.3224

Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.

Keywords: kynurenine; age; bone; kyn ... See more keywords

Promoting epithelial-to-mesenchymal transition by d-kynurenine via activating aryl hydrocarbon receptor

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recommendations! Published in 2018 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-018-3323-y

Abstract: Epithelial-to-mesenchymal transition (EMT) is believed to play key roles in the process of cancer metastasis. The molecular changes during EMT are characterized by the down-regulation of epithelial proteins, such as E-cadherin, and the up-regulation of… read more here.

Keywords: kynurenine; mesenchymal transition; hydrocarbon receptor; aryl hydrocarbon ... See more keywords

Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.

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recommendations! Published in 2018 at "Cancer cell"

DOI: 10.1016/j.ccell.2018.02.005

Abstract: Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show that tumor-repopulating cells (TRCs) drive PD-1 upregulation in CD8+ T cells through a transcellular… read more here.

Keywords: kynurenine; tumor repopulating; repopulating cells; cd8 cells ... See more keywords

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.

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recommendations! Published in 2019 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2018.12.012

Abstract: Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the… read more here.

Keywords: kynurenine; like behaviors; stress; depressive like ... See more keywords
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Impaired metabolism of kynurenine and its metabolites in CSF of parkinson’s disease

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recommendations! Published in 2020 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.134576

Abstract: AIM The kynurenine (KYN) pathway plays an important role in degrading molecules responsible for oxidative stress in the central nervous system (CNS), but can also have neurotoxic effects. Both 3-hydroxykynurenine (3-HK) and quinolinic acid are… read more here.

Keywords: kynurenine; kyn pathway; csf levels; parkinson disease ... See more keywords

Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study

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recommendations! Published in 2019 at "Psychoneuroendocrinology"

DOI: 10.1016/j.psyneuen.2019.104371

Abstract: Inflammation has an important physiological influence on mood and behavior. Kynurenine metabolism is hypothesized to be a pathway linking inflammation and depressed mood, in part through the impact of kynurenine metabolites on glutamate neurotransmission in… read more here.

Keywords: kynurenine; endotoxin; inflammation; mood ... See more keywords

Single cell analysis of kynurenine and System L amino acid transport in T cells

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-04366-7

Abstract: The tryptophan metabolite kynurenine has critical immunomodulatory properties and can function as an aryl hydrocarbon receptor (AHR) ligand. Here we show that the ability of T cells to transport kynurenine is restricted to cells activated… read more here.

Keywords: single cell; kynurenine; transport; system amino ... See more keywords

P354 Tryptophan metabolites as predictive biomarkers for dietary therapy outcomes in paediatric Crohn's disease

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.0484

Abstract: Crohn's disease (CD) exclusion diet combined with partial enteral nutrition (CDED+PEN) and exclusive enteral nutrition (EEN) are effective in inducing remission in mild-to-moderate paediatric CD. While tolerance is higher with CDED+PEN than with EEN, a… read more here.

Keywords: therapy; kynurenine; remission; tryptophan ... See more keywords

Immunomodulatory actions of a kynurenine-derived endogenous electrophile

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1101/2022.02.08.479451

Abstract: The inflammatory upregulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene (Kyn-CKA), as evidenced by the accumulation of… read more here.

Keywords: kyn cka; immunomodulatory actions; kynurenine; kynurenine derived ... See more keywords

Intracellular kynurenine promotes acetaldehyde accumulation, further inducing the apoptosis in soil beneficial fungi Trichoderma guizhouense NJAU4742 under acid stress.

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recommendations! Published in 2022 at "Environmental microbiology"

DOI: 10.1111/1462-2920.16286

Abstract: In this study, the growth of fungi T. guizhouense NJAU4742 was significantly inhibited under acid stress, and the genes related to acid stress were identified based on transcriptome analysis. Four genes including tna1, adh2/4, and… read more here.

Keywords: stress; guizhouense njau4742; kynurenine; accumulation ... See more keywords