Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3224
Abstract: Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age‐associated increase in the generation of reactive oxygen species has been frequently implicated.… read more here.
Keywords: kynurenine; age; bone; kyn ... See more keywords
Promoting epithelial-to-mesenchymal transition by d-kynurenine via activating aryl hydrocarbon receptor
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3323-y
Abstract: Epithelial-to-mesenchymal transition (EMT) is believed to play key roles in the process of cancer metastasis. The molecular changes during EMT are characterized by the down-regulation of epithelial proteins, such as E-cadherin, and the up-regulation of… read more here.
Keywords: kynurenine; mesenchymal transition; hydrocarbon receptor; aryl hydrocarbon ... See more keywords
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.02.005
Abstract: Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms underlying PD-1 upregulation in tumor-infiltrating T cells remain an enigma. Here, we show that tumor-repopulating cells (TRCs) drive PD-1 upregulation in CD8+ T cells through a transcellular… read more here.
Keywords: kynurenine; tumor repopulating; repopulating cells; cd8 cells ... See more keywords
Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.12.012
Abstract: Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the… read more here.
Keywords: kynurenine; like behaviors; stress; depressive like ... See more keywords
Impaired metabolism of kynurenine and its metabolites in CSF of parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134576
Abstract: AIM The kynurenine (KYN) pathway plays an important role in degrading molecules responsible for oxidative stress in the central nervous system (CNS), but can also have neurotoxic effects. Both 3-hydroxykynurenine (3-HK) and quinolinic acid are… read more here.
Keywords: kynurenine; kyn pathway; csf levels; parkinson disease ... See more keywords
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study
Sign Up to like & getrecommendations! Published in 2019 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2019.104371
Abstract: Inflammation has an important physiological influence on mood and behavior. Kynurenine metabolism is hypothesized to be a pathway linking inflammation and depressed mood, in part through the impact of kynurenine metabolites on glutamate neurotransmission in… read more here.
Keywords: kynurenine; endotoxin; inflammation; mood ... See more keywords
Single cell analysis of kynurenine and System L amino acid transport in T cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04366-7
Abstract: The tryptophan metabolite kynurenine has critical immunomodulatory properties and can function as an aryl hydrocarbon receptor (AHR) ligand. Here we show that the ability of T cells to transport kynurenine is restricted to cells activated… read more here.
Keywords: single cell; kynurenine; transport; system amino ... See more keywords
Immunomodulatory actions of a kynurenine-derived endogenous electrophile
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.02.08.479451
Abstract: The inflammatory upregulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene (Kyn-CKA), as evidenced by the accumulation of… read more here.
Keywords: kyn cka; immunomodulatory actions; kynurenine; kynurenine derived ... See more keywords
Intracellular kynurenine promotes acetaldehyde accumulation, further inducing the apoptosis in soil beneficial fungi Trichoderma guizhouense NJAU4742 under acid stress.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental microbiology"
DOI: 10.1111/1462-2920.16286
Abstract: In this study, the growth of fungi T. guizhouense NJAU4742 was significantly inhibited under acid stress, and the genes related to acid stress were identified based on transcriptome analysis. Four genes including tna1, adh2/4, and… read more here.
Keywords: stress; guizhouense njau4742; kynurenine; accumulation ... See more keywords
A mood state‐specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder
Sign Up to like & getrecommendations! Published in 2019 at "Bipolar Disorders"
DOI: 10.1111/bdi.12814
Abstract: Cytokines are thought to contribute to the pathogenesis of psychiatric symptoms by kynurenine pathway activation. Kynurenine metabolites affect neurotransmission and can cause neurotoxicity. We measured inflammatory markers in patients with bipolar disorder (BD) and studied… read more here.
Keywords: kynurenine; mood state; state specific; specific interaction ... See more keywords
Abstract 2920: Metabolic modulation of the tumor microenvironment using Synthetic Biotic™ Medicines
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2920
Abstract: Background: The immunosuppressive milieu found within the tumor microenvironment (TME) has long been understood to be a key driver of tumor initiation and progression. More recently it has been appreciated that metabolites derived from biosynthetic… read more here.
Keywords: kynurenine; synthetic biotic; biotic medicines; syn ... See more keywords