Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms
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DOI: 10.1016/j.ebiom.2022.103833
Abstract: Summary Background The infantile spasms syndrome is an early-onset epileptic encephalopathy presenting in the first 2 years of life, often with severe developmental consequences. The role of the gut microbiota and metabolism in infantile spasms… read more here.
Keywords: gut microbiota; kynurenine metabolism; microbiota; infantile spasms ... See more keywords
Regulation of kynurenine metabolism by a ketogenic diet[S]
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DOI: 10.1194/jlr.m079251
Abstract: Ketogenic diets (KDs) are increasingly utilized as treatments for epilepsy, other neurological diseases, and cancer. Despite their long history in suppressing seizures, the distinct molecular mechanisms of action of KDs are still largely unknown. The… read more here.
Keywords: regulation kynurenine; metabolism ketogenic; kynurenine metabolism; ketogenic diet ... See more keywords
A model of dopamine and serotonin-kynurenine metabolism in cortisolemia: Implications for depression
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DOI: 10.1371/journal.pcbi.1008956
Abstract: A major factor contributing to the etiology of depression is a neurochemical imbalance of the dopaminergic and serotonergic systems, which is caused by persistently high levels of circulating stress hormones. Here, a computational model is… read more here.
Keywords: kynurenine; depression; serotonin; kynurenine metabolism ... See more keywords
Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT—A Systematic Review
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DOI: 10.3390/ph15111439
Abstract: The kynurenine pathway of tryptophan (Trp) metabolism generates multiple biologically active metabolites (kynurenines) that have been implicated in neuropsychiatric disorders. It has been suggested that modulation of kynurenine metabolism could be involved in the therapeutic… read more here.
Keywords: metabolism; trp kynurenines; kynurenine metabolism; systematic review ... See more keywords