Full-length in meso structure and mechanism of rat kynurenine 3-monooxygenase inhibition
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DOI: 10.1038/s42003-021-01666-5
Abstract: The structural mechanisms of single-pass transmembrane enzymes remain elusive. Kynurenine 3-monooxygenase (KMO) is a mitochondrial protein involved in the eukaryotic tryptophan catabolic pathway and is linked to various diseases. Here, we report the mammalian full-length… read more here.
Keywords: structure; transmembrane; full length; kynurenine monooxygenase ... See more keywords
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010366
Abstract: Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is well known to play a critical function in cancer, autoimmune and neurodegenerative diseases. However, its role in host-pathogen interactions has not been characterized yet. Herein, we… read more here.
Keywords: ca2 influx; nmdar ca2; kynurenine monooxygenase; viral infections ... See more keywords
Expression of Canine Kynurenine 3-Monooxygenase by Baculovirus for Canine Mammary Tumor Diagnosis
Sign Up to like & getrecommendations! Published in 2020 at "Pakistan Veterinary Journal"
DOI: 10.29261/pakvetj/2020.012
Abstract: Received: Revised: Accepted: Published online: July 28, 2019 January 05, 2020 January 09, 2020 February 03, 2020 Kynurenine 3-monooxygenase (KMO), an outer mitochondrial membrane enzyme that is central to the kynurenine pathway, has been demonstrated… read more here.
Keywords: sf9 cells; canine; kynurenine monooxygenase; baculovirus ... See more keywords
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer
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DOI: 10.3389/fonc.2021.620361
Abstract: Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Because of the lack of reliable prognostic and predictive biomarkers for CRC, most patients are often diagnosed at a late stage. The tryptophan–kynurenine pathway plays… read more here.
Keywords: colorectal cancer; kynurenine monooxygenase; expression; crc ... See more keywords
Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma
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DOI: 10.3390/antiox11020315
Abstract: Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). KMO activity has been implicated in several major… read more here.
Keywords: kynurenine monooxygenase; kmo activity; kmo; brain ... See more keywords
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
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DOI: 10.3390/molecules27010273
Abstract: Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan. Under inflammatory conditions, however, there is an upregulation of the KP enzymes, particularly kynurenine 3-monooxygenase (KMO).… read more here.
Keywords: kynurenine pathway; kynurenine monooxygenase; pathway kynurenine; monooxygenase inhibitors ... See more keywords