Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114899
Abstract: The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the… read more here.
Keywords: syn; kyp 2047; chaperone mediated; mediated autophagy ... See more keywords
KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13143444
Abstract: Simple Summary Glioblastoma (GB) is the most aggressive brain tumor characterized by necrosis, excessive proliferation, and invasiveness. Despite relevant progress in conventional treatments, the survival rate for patients with GB remains low. The present study… read more here.
Keywords: kyp 2047; angiogenesis apoptosis; angiogenesis; study ... See more keywords