Resveratrol downregulates PCSK9 expression and attenuates steatosis through estrogen receptor α-mediated pathway in L02 cells.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.05.019
Abstract: Proprotein convertase subtilisin kexin type 9 (PCSK9) is a promising target for treating dyslipidemia and atherosclerosis. Circulating PCSK9 levels are closely related to hepatic steatosis severity and endogenous estrogen levels. Resveratrol (RSV) is a phytoestrogens… read more here.
Keywords: pcsk9 expression; rsv; expression; steatosis ... See more keywords
Combined RNA-seq and molecular biology technology revealed the protective effect of Cyclocarya paliurus polysaccharide on H2O2-induced oxidative damage in L02 cells thought regulating mitochondrial function, oxidative stress and PI3K/Akt and MAPK signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Food research international"
DOI: 10.1016/j.foodres.2022.111080
Abstract: Targeting attenuates oxidative damage may serve as a promising strategy for chronic diseases therapy. Cyclocarya paliurus polysaccharide (CP) had shown promising protection effects on L02 cells in oxidative damage. However, its mechanism remains elusive. Here,… read more here.
Keywords: biology; oxidative damage; pi3k akt; function ... See more keywords
Hexabromocyclododecanes promoted autophagy through the PI3K/Akt/mTOR pathway in L02 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of environmental management"
DOI: 10.1016/j.jenvman.2019.05.031
Abstract: As additive brominated flame retardants, hexabromocyclododecanes (HBCDs) are being widely used in diverse artificial materials and products, including thermal insulation building materials, housings of electronic equipment, and upholstery textiles. Toxicology studies have shown that HBCDs… read more here.
Keywords: l02; l02 cells; akt mtor; pi3k akt ... See more keywords
Di‐(2‐ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPAR&ggr;
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.12.010
Abstract: Abstract Di‐(2‐ethylhexyl)‐phthalate (DEHP), a ubiquitous industrial pollutant in our daily life, has been reported to cause adverse effects on glucose homeostasis and insulin sensitivity in epidemiological studies previously. Recently, it has been reported to be… read more here.
Keywords: receptor; insulin; ppar ggr; l02 cells ... See more keywords
Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology research"
DOI: 10.1039/c9tx00220k
Abstract: Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified. This… read more here.
Keywords: hyperoside silybin; dmy hyperoside; hepatotoxicity; silybin ... See more keywords
Dexmedetomidine impairs P-glycoprotein-mediated efflux function in L02 cells via the adenosine 5′-monophosphate-activated protein kinase/nuclear factor-κB pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8549
Abstract: Dexmedetomidine (DEX) a type of the anaesthetic that has been widely used in anaesthesia and intensive care. However, whether DEX affects the pharmacokinetics of drugs remains elusive. As hepatic P-glycoprotein (P-gp) serves a critical role… read more here.
Keywords: dex; monophosphate activated; activated protein; adenosine monophosphate ... See more keywords