Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13054
Abstract: The study presented focuses on the role of the neuronal cell adhesion molecule L1CAM in retinoblastoma (RB), the most common malignant intraocular childhood tumor. L1CAM is differentially expressed in a variety of human cancers and… read more here.
Keywords: cell lines; l1cam; role; l1cam retinoblastoma ... See more keywords
A new frameshift mutation in L1CAM producing X‐linked hydrocephalus
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1031
Abstract: X‐linked hydrocephalus (XLH), characterized by mental retardation and bilateral adducted thumbs, often come out to be a genetic disorder of L1CAM. It codes the protein L1 cell adhesion molecule (L1CAM), playing a crucial role in… read more here.
Keywords: linked hydrocephalus; l1cam; mutation l1cam; frameshift mutation ... See more keywords
C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2767-y
Abstract: Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines… read more here.
Keywords: rela; yap1; l1cam; c11orf95 rela ... See more keywords
L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0458-y
Abstract: Pancreas cancer cells have a tendency to invade along nerves. Such cancerous nerve invasion (CNI) is associated with poor outcome; however, the exact mechanism that drives cancer cells to disseminate along nerves is unknown. Immunohistochemical… read more here.
Keywords: pancreas cancer; invasion; l1cam; expression ... See more keywords
EP573 The expression of L1CAM and β-catenin in endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-esgo.630
Abstract: Introduction/Background Endometrial cancer is a fourth most common of female cancer and its prevalence tend to increase in the last decade especially in developing countries. It is important to gain the knowledge of endometrial cancer… read more here.
Keywords: invasion; l1cam; catenin; endometrial carcinoma ... See more keywords
Transcription Factors Leading to High Expression of Neuropeptide L1CAM in Brain Metastases from Lung Adenocarcinoma and Clinical Prognostic Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Disease Markers"
DOI: 10.1155/2021/8585633
Abstract: Background There is a lack of understanding of the development of metastasis in lung adenocarcinoma (LUAD). This study is aimed at exploring the upstream regulatory transcription factors of L1 cell adhesion molecule (L1CAM) and to… read more here.
Keywords: expression; high expression; transcription factors; l1cam ... See more keywords
Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1157
Abstract: Purpose: Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been… read more here.
Keywords: cholangiocarcinoma; l1cam; immuno pet; ca10 ... See more keywords
Abstract 1772: Development of a novel L1CAM-targeted CAR-T, CX804, and its therapeutic efficacy in ovarian and gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1772
Abstract: L1 cell adhesion molecule (L1CAM) is involved in cancer development and aberrantly expressed in various tumor. It is also associated with aggressive progression, metastasis, and poor prognosis. Public database, a Kaplan-Meier plotter (http://www.kmplot.com) shows that… read more here.
Keywords: ovarian gastric; cx804; l1cam; car ... See more keywords
L1CAM expression in human gastrointestinal tract development: From tongue to colon-rectum
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Public Health Research"
DOI: 10.1177/22799036231165624
Abstract: Background: L1CAM (L1 cell adhesion molecule) is a member of the L1 family of neural adhesion molecules, involved in the development of multiple organs and tissues, including kidneys, the enteric nervous system, and adrenal glands.… read more here.
Keywords: tongue; development; l1cam; tract development ... See more keywords
Exploring biomarkers and prognostic factors in uterine carcinosarcoma: An insight into L1CAM, CDX2, p53, and MSI status
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285447
Abstract: Background Uterine Carcinosarcomas (UCS) are a rare type of cancer composed of an admixture of high-grade carcinomatous and sarcomatous elements. Clinicopathological prognostic factors in UCS are well established, but studies that approach the impact of… read more here.
Keywords: prognostic factors; uterine carcinosarcoma; l1cam; cdx2 p53 ... See more keywords
Expression of L1 Cell Adhesion Molecule (L1CAM) in extracellular vesicles in the human spinal cord during development.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202209_29651
Abstract: OBJECTIVE L1 cell adhesion molecule (L1CAM) is a glycoprotein characterized by three components: an extracellular region, a transmembrane segment, and a cytoplasmic tail. L1CAM is expressed in multiple human cells, including neurons. The neural cell… read more here.
Keywords: cord; l1cam; human spinal; adhesion molecule ... See more keywords