Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
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DOI: 10.1038/nature25179
Abstract: Transposable elements, also known as transposons, are now recognized not only as parasitic DNA, the spread of which in the genome must be controlled by the host, but also as major players in genome evolution… read more here.
Keywords: genome wide; silencing euchromatic; euchromatic l1s; l1s ... See more keywords
An Increased Burden of Highly Active Retrotransposition Competent L1s Is Associated with Parkinson’s Disease Risk and Progression in the PPMI Cohort
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DOI: 10.3390/ijms21186562
Abstract: Long interspersed element-1 (LINE-1/L1s) contributes 17% of the human genome with more than 1 million elements present; however, fewer than 100 of these have evidence for being retrotransposition competent (RC). In addition to those RC-L1s… read more here.
Keywords: disease; reference; l1s; highly active ... See more keywords