L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
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DOI: 10.1161/circresaha.122.321227
Abstract: Background: L-2-hydroxyglutarate (L2HG) couples mitochondrial and cytoplasmic energy metabolism to support cellular redox homeostasis. Under oxygen-limiting conditions, mammalian cells generate L2HG to counteract the adverse effects of reductive stress induced by hypoxia. Very little is… read more here.
Keywords: l2hg accumulation; ischemia; hydroxyglutarate; spectroscopy ... See more keywords