The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1137
Abstract: The highly conserved Notch pathway transmits signals between neighboring cells to elicit distinct downstream transcriptional programs. In given contexts, Notch is a major regulator of cell fate specification, proliferation, and apoptosis, such that aberrant Notch… read more here.
Keywords: rbpj; structure; transcription; l3mbtl3 ... See more keywords
OS12.3 L3MBTL3 is a novel suppressor of medulloblastoma tumorigenesis
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.075
Abstract: Medulloblastoma is the most common malignant brain tumor of childhood. Therapeutic approaches to medulloblastoma have led to significant improvements but are achieved at a high cost to quality of life. Alternative therapeutic approaches are needed… read more here.
Keywords: medulloblastoma tumorigenesis; medulloblastoma; l3mbtl3; suppressor medulloblastoma ... See more keywords