A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.45851
Abstract: ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states (steady-state desensitization or… read more here.
Keywords: mechanism controls; desensitization; like mechanism; l415 n416 ... See more keywords