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   Articles with "l858r" as a keyword



Binding mechanism of kinase inhibitors to EGFR and T790M, L858R and L858R/T790M mutants through structural and energetic analysis.

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recommendations! Published in 2018 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.07.042

Abstract: Experimental studies have demonstrated that L858R mutation in the EGF receptor (EGFR) confers tumor sensitivity whereas T790M and L858R/T790M mutations cause resistance to tyrosine kinase inhibitors in patients with non-small cell lung cancer. Theoretical studies… read more here.

Keywords: egfr; l858r; analysis; t790m l858r ... See more keywords

T6496 targeting EGFR mediated by T790M or C797S mutant: machine learning, virtual screening and bioactivity evaluation study

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recommendations! Published in 2024 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2023.2300756

Abstract: Abstract Acquired resistance to EGFR is a major impediment in lung cancer treatment, highlighting the urgent need to discover novel compounds to overcome EGFR drug resistance. In this study, we utilized in silico methods and… read more here.

Keywords: c797s; l858r; virtual screening; machine learning ... See more keywords

Real world treatment patterns, healthcare resource use and costs in patients with advanced or metastatic non-small cell lung cancer by EGFR mutation type

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recommendations! Published in 2024 at "Journal of Medical Economics"

DOI: 10.1080/13696998.2024.2309838

Abstract: Abstract Aims This study described treatment patterns, healthcare resource utilization (HRU) and costs among advanced or metastatic non-small cell lung cancer (a/mNSCLC) patients with different epidermal growth factor receptor (EGFR) mutation types. Materials and methods… read more here.

Keywords: treatment; exon19del; l858r; egfr mutation ... See more keywords

Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR)

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recommendations! Published in 2020 at "Molecules"

DOI: 10.3390/molecules25122914

Abstract: Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for… read more here.

Keywords: egfr l858r; l858r; h1975; l858r t790m ... See more keywords

Differential MicroRNA Expression between EGFR T790M and L858R Mutated Lung Cancer

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recommendations! Published in 2018 at "Journal of Pathology and Translational Medicine"

DOI: 10.4132/jptm.2018.07.29

Abstract: Background MicroRNAs (miRNAs) are short, non-coding RNAs that mediate post-transcriptional gene regulation. They are commonly deregulated in human malignancies, including non-small cell lung cancer (NSCLC). The aim of this study is to investigate miRNA expression… read more here.

Keywords: egfr t790m; l858r; mir; group ... See more keywords