Binding mechanism of kinase inhibitors to EGFR and T790M, L858R and L858R/T790M mutants through structural and energetic analysis.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.042
Abstract: Experimental studies have demonstrated that L858R mutation in the EGF receptor (EGFR) confers tumor sensitivity whereas T790M and L858R/T790M mutations cause resistance to tyrosine kinase inhibitors in patients with non-small cell lung cancer. Theoretical studies… read more here.
Keywords: egfr; l858r; analysis; t790m l858r ... See more keywords
Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR)
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DOI: 10.3390/molecules25122914
Abstract: Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for… read more here.
Keywords: egfr l858r; l858r; h1975; l858r t790m ... See more keywords
Differential MicroRNA Expression between EGFR T790M and L858R Mutated Lung Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pathology and Translational Medicine"
DOI: 10.4132/jptm.2018.07.29
Abstract: Background MicroRNAs (miRNAs) are short, non-coding RNAs that mediate post-transcriptional gene regulation. They are commonly deregulated in human malignancies, including non-small cell lung cancer (NSCLC). The aim of this study is to investigate miRNA expression… read more here.
Keywords: egfr t790m; l858r; mir; group ... See more keywords