A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-017-1301-x
Abstract: BackgroundThe current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-adjuvanting peptide of Mtb (L91), successfully generated enduring… read more here.
Keywords: bcg; l91; bcg vaccine; memory ... See more keywords
Case Report: Loss-of-function TRPM4 mutation p.L91Δ implicated in progressive cardiac conduction defect
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2025.1681438
Abstract: Background The calcium-activated non-specific cation channel TRPM4 mediates membrane depolarization in many cell types, including cardiomyocytes and Purkinje cells. Rare genetic alterations in the TRPM4 gene can cause familial cases of progressive cardiac conduction defects… read more here.
Keywords: progressive cardiac; l91; trpm4; loss function ... See more keywords