Articles with "labdane" as a keyword



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Labdane conjugates protect cardiomyocytes from doxorubicin‐induced cardiotoxicity

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Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.22014

Abstract: The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies with cardioprotective effects, a series of new labdane conjugates were prepared (6a–6c… read more here.

Keywords: labdane; induced cardiotoxicity; activity; labdane conjugates ... See more keywords
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Synthesis of Sulfur-Containing Analogues of Hedychenone, a Labdane Diterpenoid from Hedychium spicatum.

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Published in 2022 at "Journal of natural products"

DOI: 10.1021/acs.jnatprod.2c00112

Abstract: The labdane diterpene hedychenone, isolated from Hedychium spicatum, is an example of a furan-containing natural product. Herein, a new and efficient method for the synthesis of 19 new thio analogues of hedychenone is reported. The… read more here.

Keywords: analogues hedychenone; hedychium spicatum; labdane; synthesis ... See more keywords
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Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels

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Published in 2022 at "Marine Drugs"

DOI: 10.3390/md20080515

Abstract: Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was… read more here.

Keywords: labdane; cav1 channel; novel labdane; diterpenes based ... See more keywords

Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species

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Published in 2020 at "Molecules"

DOI: 10.3390/molecules25081808

Abstract: The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were… read more here.

Keywords: salvia cinnabarina; communic acid; trans communic; labdane diterpenoids ... See more keywords