New labdane diterpenoids from Alpinia galanga: A new type of GLP‐1 secretagogues targeting the PKA‐CREB and PI3K‐Akt signaling axes
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400383
Abstract: Glucagon‐like peptide‐1 (GLP‐1) secretagogues are fascinating pharmacotherapies to overcome the defects of GLP‐1 analogs and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in treating diabetes and obesity. To discover new GLP‐1 secretagogues from natural sources, alpigalangols A‐Q (1–17),… read more here.
Keywords: glp secretagogues; alpinia galanga; new labdane; labdane ... See more keywords
Labdane conjugates protect cardiomyocytes from doxorubicin‐induced cardiotoxicity
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DOI: 10.1002/ddr.22014
Abstract: The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies with cardioprotective effects, a series of new labdane conjugates were prepared (6a–6c… read more here.
Keywords: labdane; induced cardiotoxicity; activity; labdane conjugates ... See more keywords
Synthesis of Sulfur-Containing Analogues of Hedychenone, a Labdane Diterpenoid from Hedychium spicatum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00112
Abstract: The labdane diterpene hedychenone, isolated from Hedychium spicatum, is an example of a furan-containing natural product. Herein, a new and efficient method for the synthesis of 19 new thio analogues of hedychenone is reported. The… read more here.
Keywords: analogues hedychenone; hedychium spicatum; labdane; synthesis ... See more keywords
Isolation, structural elucidation, and integrated biological and computational evaluation of antidiabetic labdane diterpenes from Curcuma zedoaria rhizomes
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DOI: 10.1039/d5ra03418c
Abstract: The phytochemical investigation of the EtOAc-soluble extract of the rhizomes of Curcuma zedoaria (Berg.) Roscoe led to the isolation of five labdane-type diterpenes, including a previously undescribed norditerpene, zedolabdin A (CZ1), and four known compounds… read more here.
Keywords: curcuma zedoaria; isolation structural; labdane; cz4 ... See more keywords
Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway
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DOI: 10.1055/a-2440-5166
Abstract: Abstract Leonurus sibiricus , a widely cultivated herbaceous plant in Asian countries, exhibits diverse medicinal applications. Recent studies emphasize its pharmacological properties and efficacy in promoting bone health. In addition to the known compounds and… read more here.
Keywords: anti inflammatory; leonurus sibiricus; labdane; inflammatory ... See more keywords
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels
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DOI: 10.3390/md20080515
Abstract: Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was… read more here.
Keywords: labdane; cav1 channel; novel labdane; diterpenes based ... See more keywords
Structural Elucidation of Malonylcommunol and 6β-Hydroxy-trans-communic Acid, Two Undescribed Diterpenes from Salvia cinnabarina. First Examples of Labdane Diterpenoids from a Mexican Salvia Species
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25081808
Abstract: The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were… read more here.
Keywords: salvia cinnabarina; communic acid; trans communic; labdane diterpenoids ... See more keywords