Agathadiol, a labdane diterpenoid from juniper berries, is a positive allosteric modulator of CB1R.
Sign Up to like & getrecommendations! Published in 2021 at "Fitoterapia"
DOI: 10.1016/j.fitote.2021.105059
Abstract: The neutral fraction of a juniper (Juniperus communis L.) berries acetone extract could positively modulate the activity of type 1 - cannabinoid receptor (CB1R). Bioactivity-directed fractionation identified the labdane diterpenoid agathadiol (4) as a positive… read more here.
Keywords: allosteric modulator; cb1r; juniper; labdane diterpenoid ... See more keywords
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function
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DOI: 10.1111/bph.15993
Abstract: Alveolar macrophages (AMs) contribute to airway inflammation and remodelling in allergic asthma. Calcaratarin D (CalD), a labdane diterpenoid from rhizomes of the medicinal plant Alpinia calcarata, has recently been shown to possess anti‐inflammatory properties. The… read more here.
Keywords: asthma via; mouse asthma; calcaratarin labdane; diterpenoid attenuates ... See more keywords