Novel [18F]-Labeled Meta-Bromobenzylguanidine Derivatives: Potential Positron Emission Tomography Imaging Probes for the Norepinephrine Transporter.
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DOI: 10.1021/acs.molpharmaceut.1c00429
Abstract: To develop novel norepinephrine transporter (NET)-targeting positron emission tomography (PET) probes with optimal pharmacokinetic properties, a series of meta-bromobenzylguanidine derivatives was synthesized. 4-Fluorodiethoxyethane-3-bromobenzylguanidine (compound 12) showed relatively good affinity for the NET (IC50 = 1.00… read more here.
Keywords: norepinephrine transporter; labeled meta; positron emission; bromobenzylguanidine derivatives ... See more keywords