Enzymological Characterization of 64Cu-Labeled Neprilysin Substrates and Their Application for Modulating the Renal Clearance of Targeted Radiopharmaceuticals.
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DOI: 10.1021/acs.jmedchem.2c01472
Abstract: The applicability of radioligands for targeted endoradionuclide therapy is limited due to radiation-induced toxicity to healthy tissues, in particular to the kidneys as primary organs of elimination. The targeting of enzymes of the renal brush… read more here.
Keywords: cleavable linkers; labeled neprilysin; 64cu labeled; enzymological characterization ... See more keywords