Direct 18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F- on Phosphonate Prostheses.
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DOI: 10.1021/acs.orglett.1c01211
Abstract: We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other… read more here.
Keywords: nucleophilic substitution; 18f labeling; direct 18f; labeling biomolecules ... See more keywords