Identification of naringin metabolites mediated by human intestinal microbes with stable isotope‐labeling method and UFLC‐Q‐TOF‐MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.08.039
Abstract: HighlightsA total of 13 naringin metabolites mediated by human intestinal microbes were identified, among which 5 were reported for the first time.Naringin underwent extensive phase I metabolism in human intestinal microbes.Microbial metabolic profiles of naringin… read more here.
Keywords: intestinal microbes; isotope labeling; mediated human; labeling method ... See more keywords
An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc03812e
Abstract: DNA 5-hydroxymethyluracil (5hmU) is a thymine modification existing in the genomes of various organisms. The post-replicative formation of 5hmU occurs via hydroxylation of thymine by ten-eleven translocation (TET) dioxygenases in mammals and J-binding proteins (JBPs)… read more here.
Keywords: enzyme mediated; bioorthogonal labeling; labeling method; mediated bioorthogonal ... See more keywords
Abstract 3885: A ubiquitin-specific proximity labeling method to study drug-induced ubiquitylation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3885
Abstract: Targeted protein degradation is a promising therapeutic paradigm that offers new ways to disrupt protein functions. Currently, most studies that characterize the pharmacological effects of protein degraders utilize target-specific assays and global proteomics. However, information… read more here.
Keywords: labeling method; specific proximity; ubiquitylation; proximity labeling ... See more keywords