Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00099
Abstract: Antibody-drug conjugates (ADCs) have demonstrated great therapeutic potential due to their ability to target the delivery of potent cytotoxins. However, the heterogeneous nature of conventional drug conjugation strategies can affect the safety, efficacy, and stability… read more here.
Keywords: igg; ligation; labeling native; efficient labeling ... See more keywords
Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b10490
Abstract: Chemical biology research often requires precise covalent attachment of labels to the native proteins. Such methods are sought after to probe, design, and regulate the properties of proteins. At present, this demand is largely unmet… read more here.
Keywords: native proteins; site selective; labeling native; site ... See more keywords