Early‐Stage Incorporation Strategy for Regioselective Labeling of Peptides using the 2‐Cyanobenzothiazole/1,2‐Aminothiol Bioorthogonal Click Reaction
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DOI: 10.1002/open.201700191
Abstract: Abstract Herein, we describe a synthetic strategy for the regioselective labeling of peptides by using a bioorthogonal click reaction between 2‐cyanobenzothiazole (CBT) and a 1,2‐aminothiol moiety. This methodology allows for the facile and site‐specific modification… read more here.
Keywords: click reaction; strategy regioselective; labeling peptides; reaction ... See more keywords
Reagents for Isobaric Labeling Peptides in Quantitative Proteomics.
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DOI: 10.1021/acs.analchem.8b00321
Abstract: Currently, the commercial reagents for isobaric peptides labeling (TMT and iTRAQ) have some drawbacks, such as high cost in experiments, especially in quantitation for the modified peptides, and inconvenient handling for variable sizes of samples.… read more here.
Keywords: reagents isobaric; chemistry; labeling peptides; quantitative proteomics ... See more keywords
Coordination to Imidazole Ring Switches on Phosphorescence of Platinum Cyclometalated Complexes: The Route to Selective Labeling of Peptides and Proteins via Histidine Residues.
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DOI: 10.1021/acs.bioconjchem.6b00598
Abstract: In this study, we have shown that substitution of chloride ligand for imidazole (Im) ring in the cyclometalated platinum complex Pt(phpy)(PPh3)Cl (1; phpy, 2-phenylpyridine; PPh3, triphenylphosphine), which is nonemissive in solution, switches on phosphorescence of… read more here.
Keywords: switches phosphorescence; labeling peptides; imidazole ring; peptides proteins ... See more keywords