Tunable Activated Esters Enable Lysine-Selective Protein Labeling and Profiling.
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DOI: 10.1021/acs.analchem.4c02215
Abstract: Lysine residues on protein surfaces are abundant and often found in enzyme active sites, making them critical targets for studying undruggable proteins. However, the varied microenvironment surrounding lysine residues results in a wide range of… read more here.
Keywords: esters enable; activated esters; labeling profiling; tunable activated ... See more keywords
Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae150
Abstract: Abstract Chemical modifications in RNAs play crucial roles in diversifying their structures and regulating numerous biochemical processes. Since the 1990s, several hydrophobic prenyl-modifications have been discovered in various RNAs. Prenyl groups serve as precursors for… read more here.
Keywords: bioorthogonal labeling; modified rna; isopentenyladenosine i6a; labeling profiling ... See more keywords