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Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.10.010
Abstract: Genetic variation fuels Darwinian evolution, yet spontaneous mutation rates are maintained at low levels to ensure cellular viability. Low mutation rates preclude the exhaustive exploration of sequence space for protein evolution and genome engineering applications,…
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Keywords:
laboratory diversification;
evolution;
diversification;
modern methods ... See more keywords