Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?
Sign Up to like & getrecommendations! Published in 2018 at "Trends in microbiology"
DOI: 10.1016/j.tim.2018.08.002
Abstract: The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in… read more here.
Keywords: laboratory strains; strains limit; diversity homogeneous; limit discovery ... See more keywords
Laboratory strains of Escherichia coli K-12: things are seldom what they seem
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000922
Abstract: Escherichia coli K-12 was originally isolated 100 years ago and since then it has become an invaluable model organism and a cornerstone of molecular biology research. However, despite its pedigree, since its initial isolation E. coli… read more here.
Keywords: escherichia coli; strains escherichia; coli things; model organism ... See more keywords
Budding Yeast Strains and Genotype-Phenotype Mapping.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.top077735
Abstract: A small number of well-studied laboratory strains of Saccharomyces cerevisiae, mostly derived from S288C, are used in yeast research. Although powerful, studies for understanding S288C do not always capture the phenotypic essence or the genetic… read more here.
Keywords: laboratory strains; budding yeast; genotype phenotype; yeast strains ... See more keywords
Genetic diversity of laboratory strains and implications for research: The case of Aedes aegypti
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007930
Abstract: The yellow fever mosquito (Aedes aegypti), is the primary vector of dengue, Zika, and chikungunya fever, among other arboviral diseases. It is also a popular laboratory model in vector biology due to its ease of… read more here.
Keywords: laboratory strains; aedes aegypti; genetic diversity; diversity laboratory ... See more keywords