Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon
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DOI: 10.1093/molbev/msab077
Abstract: Abstract Populations of Escherichia coli selected in constant and fluctuating environments containing lactose often adapt by substituting mutations in the lacI repressor that cause constitutive expression of the lac operon. These mutations occur at a… read more here.
Keywords: repressor; lac operon; historical contingency; expression lac ... See more keywords
Diversity in lac Operon Regulation among Diverse Escherichia coli Isolates Depends on the Broader Genetic Background but Is Not Explained by Genetic Relatedness
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DOI: 10.1128/mbio.02232-19
Abstract: The lac operon of Escherichia coli is a classic model for studying gene regulation. This study has uncovered features such as the environmental input logic controlling gene expression, as well as gene expression bistability and… read more here.
Keywords: lac; coli; regulation; gene ... See more keywords