Effectiveness of &bgr;-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2017.3225
Abstract: Importance &bgr;-Lactam monotherapy and &bgr;-lactam plus macrolide combination therapy are both common empirical treatment strategies for children hospitalized with pneumonia, but few studies have evaluated the effectiveness of these 2 treatment approaches. Objective To compare… read more here.
Keywords: bgr lactam; combination therapy; lactam;
A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01803-y
Abstract: The overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coli is regulated via production of β-lactam-hydrolyzing β-lactamases enzymes. Escherichia coli O104: H4 is a multi-drug resistant strain known… read more here.
Keywords: escherichia coli; non; coli o104; lactam ... See more keywords
Impact of Beta-Lactam Allergy on Treatment of Outpatient Infections.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.10.001
Abstract: PURPOSE The most commonly reported medication allergies in the United States involve beta-lactam antibiotics, creating an important consideration for prescribers when choosing optimal treatment of infections. Currently, few data exist on outpatient prescribing patterns in… read more here.
Keywords: treatment; lactam; lactam allergy; beta lactam ... See more keywords
Evanescent Wave Optical Fiber Sensors Using Enzymatic Hydrolysis on Nanostructured Polyaniline for Detection of β-Lactam Antibiotics in Food and Environment.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c04169
Abstract: β-Lactam antibiotics such as penicillins and cephalosporins are extensively used for human infection therapy. Consistent unintended exposure to these antibiotics via food and water is known to promote antibiotic-resistant bacterial pathogenesis with high morbidity and… read more here.
Keywords: detection; lactam antibiotics; enzymatic hydrolysis; antibiotics food ... See more keywords
Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00735
Abstract: A five-step total synthesis of (±)-aspidospermidine (1) based on a lactam strategy is reported. Our synthesis features an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade to give a tricyclic ketone intermediate from a simple lactam via… read more here.
Keywords: five step; step total; total synthesis; strategy ... See more keywords
Structural and Electronic Origin of Bis-Lactam-Based High-Performance Organic Thin-Film Transistors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20168
Abstract: We describe herein the comprehensive theoretical and experimental studies on the transistor mobility of organic semiconductors by correlating a two-dimensional (2D) intermolecular interaction with thin-film morphology and the electronic coupling structure. We developed a novel… read more here.
Keywords: lactam based; lactam; bis lactam; thin film ... See more keywords
Fast Synthesis of Graphene Oxide−β-Lactam as a Residue-Free Environmental Bacterial Inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02328
Abstract: Common pathogenic bacteria contaminate the environment through various modes of transmission. It is thus crucial to develop simple preparation methods of residue-free environmental disinfectants. β-Lactam antibiotics are frequently prescribed in clinical practice to treat bacterial… read more here.
Keywords: residue free; free environmental; fast synthesis; graphene oxide ... See more keywords
Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01677j
Abstract: We present the first synthesis of β-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed in vitro immunological evaluation on 18 structurally… read more here.
Keywords: synthesis skeletally; lactam; drug allergy; synthesis ... See more keywords
Point-of-Care &bgr;-Lactam Allergy Skin Testing by Antimicrobial Stewardship Programs: A Pragmatic Multicenter Prospective Evaluation
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Infectious Diseases"
DOI: 10.1093/cid/cix512
Abstract: Background β-lactam allergy skin testing (BLAST) is recommended by antimicrobial stewardship program (ASP) guidelines, yet few studies have systematically evaluated its impact when delivered at point of care. Methods We conducted a pragmatic multicenter prospective… read more here.
Keywords: point care; lactam therapy; lactam; lactam allergy ... See more keywords
Adding Insult to Injury: Mechanistic Basis for How AmpC Mutations Allow Pseudomonas aeruginosa To Accelerate Cephalosporin Hydrolysis and Evade Avibactam
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00894-20
Abstract: Pseudomonas aeruginosa is a leading cause of nosocomial infections worldwide and notorious for its broad-spectrum resistance to antibiotics. A key mechanism that provides extensive resistance to β-lactam antibiotics is the inducible expression of AmpC β-lactamase.… read more here.
Keywords: ampc; mutations allow; resistance; lactam ... See more keywords
Epidemiology of β-Lactamase-Producing Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00047-19
Abstract: β-Lactam antibiotics have been widely used as therapeutic agents for the past 70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases. Although penicillinases in Staphylococcus aureus challenged the initial uses of penicillin, β-lactamases are… read more here.
Keywords: producing pathogens; lactamase producing; lactam; lactam containing ... See more keywords