Effectiveness of &bgr;-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2017.3225
Abstract: Importance &bgr;-Lactam monotherapy and &bgr;-lactam plus macrolide combination therapy are both common empirical treatment strategies for children hospitalized with pneumonia, but few studies have evaluated the effectiveness of these 2 treatment approaches. Objective To compare… read more here.
Keywords: bgr lactam; combination therapy; lactam;
Metal‐Catalyzed Cross‐Coupling for the Synthesis of β‐Lactam Drugs and Related Chemical Probes
Sign Up to like & getrecommendations! Published in 2025 at "Chemmedchem"
DOI: 10.1002/cmdc.202400960
Abstract: Antimicrobial resistance is a major public health threat, due to the emergence of new bacterial strains not responding to classical antibiotics. This review focuses on the use of transition metal cross‐coupling strategies used to access… read more here.
Keywords: metal catalyzed; coupling synthesis; lactam; cross coupling ... See more keywords
A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01803-y
Abstract: The overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coli is regulated via production of β-lactam-hydrolyzing β-lactamases enzymes. Escherichia coli O104: H4 is a multi-drug resistant strain known… read more here.
Keywords: escherichia coli; non; coli o104; lactam ... See more keywords
Impact of Beta-Lactam Allergy on Treatment of Outpatient Infections.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.10.001
Abstract: PURPOSE The most commonly reported medication allergies in the United States involve beta-lactam antibiotics, creating an important consideration for prescribers when choosing optimal treatment of infections. Currently, few data exist on outpatient prescribing patterns in… read more here.
Keywords: treatment; lactam; lactam allergy; beta lactam ... See more keywords
Evanescent Wave Optical Fiber Sensors Using Enzymatic Hydrolysis on Nanostructured Polyaniline for Detection of β-Lactam Antibiotics in Food and Environment.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c04169
Abstract: β-Lactam antibiotics such as penicillins and cephalosporins are extensively used for human infection therapy. Consistent unintended exposure to these antibiotics via food and water is known to promote antibiotic-resistant bacterial pathogenesis with high morbidity and… read more here.
Keywords: detection; lactam antibiotics; enzymatic hydrolysis; antibiotics food ... See more keywords
Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00735
Abstract: A five-step total synthesis of (±)-aspidospermidine (1) based on a lactam strategy is reported. Our synthesis features an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade to give a tricyclic ketone intermediate from a simple lactam via… read more here.
Keywords: five step; step total; total synthesis; strategy ... See more keywords
Structural and Electronic Origin of Bis-Lactam-Based High-Performance Organic Thin-Film Transistors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20168
Abstract: We describe herein the comprehensive theoretical and experimental studies on the transistor mobility of organic semiconductors by correlating a two-dimensional (2D) intermolecular interaction with thin-film morphology and the electronic coupling structure. We developed a novel… read more here.
Keywords: lactam based; lactam; bis lactam; thin film ... See more keywords
Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP).
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00515
Abstract: Speckle-type POZ protein (SPOP) acts as a cullin3-RING ubiquitin ligase adaptor, which facilitates the recognition and ubiquitination of substrate proteins. Previous research suggests that targeting SPOP holds promise in the treatment of clear cell renal… read more here.
Keywords: lactam derivatives; protein spop; lactam; speckle type ... See more keywords
Fast Synthesis of Graphene Oxide−β-Lactam as a Residue-Free Environmental Bacterial Inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02328
Abstract: Common pathogenic bacteria contaminate the environment through various modes of transmission. It is thus crucial to develop simple preparation methods of residue-free environmental disinfectants. β-Lactam antibiotics are frequently prescribed in clinical practice to treat bacterial… read more here.
Keywords: residue free; free environmental; fast synthesis; graphene oxide ... See more keywords
Synthesis of skeletally diverse β-lactam haptens for the in vitro diagnosis of IgE-mediated drug allergy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01677j
Abstract: We present the first synthesis of β-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed in vitro immunological evaluation on 18 structurally… read more here.
Keywords: synthesis skeletally; lactam; drug allergy; synthesis ... See more keywords
Harnessing the 1,3-azadiene-anhydride reaction for the regioselective and stereocontrolled synthesis of lactam-fused bromotetrahydropyrans by bromoetherification of lactam-tethered trisubstituted tertiary alkenols
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d4ra02523g
Abstract: Halo-cycloetherification of lactam-tethered alkenols enables the construction of oxygen-heterocycles that are fused to nitrogen heterocycles via intramolecular halonium-induced nucleophilic addition. Specifically, tetrahydropyrans (THPs) that are fused to a nitrogen heterocycle constitute the core of several… read more here.
Keywords: tertiary alkenols; lactam; lactam tethered; trisubstituted tertiary ... See more keywords