Failure of daptomycin β-Lactam combination therapy to prevent resistance emergence in Enterococcus faecium.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.10.017
Abstract: Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes… read more here.
Keywords: lactam combination; combination therapy; daptomycin lactam; enterococcus faecium ... See more keywords
Carbapenem-Nonsusceptible Pseudomonas aeruginosa Isolates from Intensive Care Units in the United States: a Potential Role for New β-Lactam Combination Agents
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00535-19
Abstract: Pseudomonas aeruginosa, a frequent pathogen in the intensive care unit (ICU), has the propensity to develop antibiotic resistance. In particular, carbapenem-nonsusceptible (NS) P. aeruginosa poses tremendous challenges, and new antibiotics will be needed to treat… read more here.
Keywords: aeruginosa isolates; lactam combination; aeruginosa; combination agents ... See more keywords