Synthesis of β-Lactam-containing Pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepines
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DOI: 10.1002/jhet.2936
Abstract: Novel tricyclic 1,4-diazepine derivatives – pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepin-2-ones – have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2]cycloaddition of functionalized ketenes to imine C═N bond, and several tetracyclic azetodiazepines which can be… read more here.
Keywords: chemistry; synthesis lactam; containing pyrido; thieno diazepines ... See more keywords
Epidemiology of β-Lactamase-Producing Pathogens
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DOI: 10.1128/cmr.00047-19
Abstract: β-Lactam antibiotics have been widely used as therapeutic agents for the past 70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases. Although penicillinases in Staphylococcus aureus challenged the initial uses of penicillin, β-lactamases are… read more here.
Keywords: producing pathogens; lactamase producing; lactam; lactam containing ... See more keywords