Two new lactam derivatives from a Sphagneticola trilobata derived fungus Penicillium rubens PQJ-2.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2122964
Abstract: A new bicyclic lactam derivatives penicilactam B (1) and a new monocyclic amide penicillamide D (2), along with four known compounds (3-6), were isolated from the fermentation broth of the derived fungus Penicillium rubens PQJ-2.… read more here.
Keywords: lactam derivatives; rubens pqj; derived fungus; fungus penicillium ... See more keywords
Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group
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DOI: 10.3390/ph15050511
Abstract: We report efficient synthetic methodologies for the preparation of 3-amino and 3-hydroxy 3-pyrrolin-2-ones (unsaturated γ-lactams) through a multicomponent reaction of amines, aldehydes and acetylene or pyruvate derivatives. The densely substituted γ-lactam substrates show in vitro… read more here.
Keywords: synthesis unsaturated; lactam derivatives; derivatives applications; unsaturated lactam ... See more keywords