Bioprospecting for β-lactam resistance genes using a metagenomics-guided strategy
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8343-0
Abstract: Emergence of new antibiotic resistance bacteria poses a serious threat to human health, which is largely attributed to the evolution and spread of antibiotic resistance genes (ARGs). In this work, a metagenomics-guided strategy consisting of… read more here.
Keywords: metagenomics guided; guided strategy; lactam resistance; resistance ... See more keywords
Beta-lactam resistance development during the treatment processes of municipal wastewater treatment plants.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.130749
Abstract: This work monitored the effect of a municipal and a village wastewater treatment plant (WWTP) technology on the fate of beta-lactam resistance genes in bacterial populations in different phases of the wastewater treatment process. In… read more here.
Keywords: lactam resistance; treatment; resistance; wastewater treatment ... See more keywords
Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0401-8
Abstract: Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, we discovered… read more here.
Keywords: reverses lactam; antivirulence; virulence; lactam resistance ... See more keywords
Morphological change of coiled bacterium Spirosoma linguale with acquisition of β-lactam resistance
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92787-8
Abstract: Spirosoma linguale is a gram-negative, coiled bacterium belonging to the family Cytophagaceae. Its coiled morphology is unique in contrast to closely related bacteria belonging to the genus Spirosoma, which have a short, rod-shaped morphology. The… read more here.
Keywords: bacterium; spirosoma linguale; lactam resistance; morphology ... See more keywords
Systematic analysis of supervised machine learning as an effective approach to predicate β-lactam resistance phenotype in Streptococcus pneumoniae
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbz056
Abstract: Streptococcus pneumoniae is the most common human respiratory pathogen, and β-lactam antibiotics have been employed to treat infections caused by S. pneumoniae for decades. β-lactam resistance is steadily increasing in pneumococci and is mainly associated… read more here.
Keywords: lactam resistance; pneumoniae; supervised machine; streptococcus pneumoniae ... See more keywords
Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02478-22
Abstract: The clinical burden of infections caused by antimicrobial resistant (AMR) pathogens is a leading threat to public health. Maintaining the effectiveness of existing antimicrobial drugs or finding ways to reintroduce drugs to which resistance is… read more here.
Keywords: mrsa lactam; purine nucleosides; lactam resistance; resistance ... See more keywords
Regulation of AmpC-Driven β-Lactam Resistance in Pseudomonas aeruginosa: Different Pathways, Different Signaling
Sign Up to like & getrecommendations! Published in 2019 at "mSystems"
DOI: 10.1128/msystems.00524-19
Abstract: The extensive use of β-lactam antibiotics and the bacterial adaptive capacity have led to the apparently unstoppable increase of antimicrobial resistance, one of the current major global health challenges. In the leading nosocomial pathogen Pseudomonas… read more here.
Keywords: lactam resistance; hyperproduction; wall derived; resistance ... See more keywords
β-Lactam resistance in veterinary β-hemolytic Streptococcus species: Are we experiencing a public health or test method crisis?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Veterinary Medical Association"
DOI: 10.2460/javma.23.03.0172
Abstract: β-Hemolytic Streptococcus (BHS) species are important pathogens with both human and veterinary significance. In human medicine, BHS are considered universally susceptible to β-lactams while BHS of veterinary origin have been reported with up to 8%… read more here.
Keywords: public health; hemolytic streptococcus; test; lactam resistance ... See more keywords
The Characterization and Beta-Lactam Resistance of Staphylococcal Community Recovered from Raw Bovine Milk
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12030556
Abstract: Staphylococci is an opportunistic bacterial population that is permanent in the normal flora of milk and poses a serious threat to animal and human health with some virulence factors and antibiotic-resistance genes. This study was… read more here.
Keywords: beta lactam; lactam resistance; resistance; milk ... See more keywords