Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
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DOI: 10.3390/antibiotics9110833
Abstract: β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge.… read more here.
Keywords: effective inhibitors; designing effective; exploit lactamases; lactamases intrinsic ... See more keywords