Synthesis of Diverse γ-Lactams via Rh-Catalyzed C(sp2)-H Addition to Aliphatic Nitriles.
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DOI: 10.1021/acs.orglett.2c01867
Abstract: We herein report an unprecedented pathway to access γ-lactams using acetonitrile analogues as coupling partners without oxidants, ligands, and Lewis acids. The reaction undergoes Rh-catalyzed C(sp2)-H addition to carbon-bound nitriles with the aid of an… read more here.
Keywords: sp2 addition; lactams via; synthesis diverse; catalyzed sp2 ... See more keywords
Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst
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DOI: 10.1039/d2ra07117g
Abstract: Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to… read more here.
Keywords: highly regioselective; lactams via; ketones ketoamides; cascade reaction ... See more keywords
Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts
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DOI: 10.1126/science.aap7503
Abstract: Guiding nitrenes away from a migration Nitrogen conventionally shares its electrons in three bonds with one or more partners. A singly bonded nitrogen, or nitrene, is exceptionally reactive and can insert itself into normally inert… read more here.
Keywords: theory; iridium; selective formation; amidation ... See more keywords