Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2016.3681
Abstract: Importance Improving emergency care of pediatric sepsis is a public health priority, but optimal early diagnostic approaches are unclear. Measurement of lactate levels is associated with improved outcomes in adult septic shock, but pediatric guidelines… read more here.
Keywords: lactate levels; sepsis; day mortality; lactate ... See more keywords
Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204808
Abstract: Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives immunosuppression and promotes tumor progression. Material‐engineered strategies for intratumoral lactate modulations demonstrate their promise for tumor immunotherapy. However, understanding of the inherent interconnections of material‐enabled… read more here.
Keywords: lactate depletion; intratumoral lactate; lactate; metabolic reprogramming ... See more keywords
Whole‐cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26254
Abstract: Many high‐value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimize the productivity of these cultures it is important to monitor cellular metabolism, for example the utilization… read more here.
Keywords: whole cell; biosensor; mammalian cell; lactate ... See more keywords
Does a normal peripheral lactate value always indicate an aerobic tissue metabolism?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.863
Abstract: Heart failure (HF) has been classically defined as a condition in which the heart is unable to deliver sufficient oxygen to match the needs of the metabolizing tissues. Dr Paul Wood was the first to… read more here.
Keywords: heart; lactate; heart failure; peripheral lactate ... See more keywords
On‐chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200214
Abstract: Early detection has led to increased survival for multiple cancers; however, the 5‐year survival rate of oral carcinoma (OC) has remained at 40% for the last several decades. Screening for OC is routinely done via… read more here.
Keywords: lactate; detection; chip dielectrophoretic; model ... See more keywords
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30661
Abstract: It is unresolved why lactate is transported to the liver for further utilization within the physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) than liver. We point out that the answer… read more here.
Keywords: protons oxygen; cori cycle; warburg effect; lactate ... See more keywords
Changes in nutrient consumption patterns of Lactobacillus fermentum mediated by sodium lactate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12295
Abstract: BACKGROUND During high-cell-density culture of Lactobacillus fermentum, the optimal pH is often maintained by adding NaOH. During cultivation at controlled pH, L. fermentum experiences osmotic stress due to the continuous accumulation of sodium lactate as… read more here.
Keywords: sodium lactate; lactobacillus fermentum; lactate; consumption ... See more keywords
Assessing potential correlation between T2 relaxation and diffusion of lactate in the mouse brain
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29395
Abstract: While diffusion and T2 relaxation are intertwined, little or no correlation exists between diffusion and T2 relaxation of intracellular metabolites in the rodent brain, as measured by diffusion‐weighted MRS at different TEs. However, situation might… read more here.
Keywords: lactate mouse; diffusion; diffusion lactate; brain ... See more keywords
Spectrally selective bSSFP using off-resonant RF excitations permits high spatiotemporal resolution 3D metabolic imaging of hyperpolarized [1-13 C]Pyruvate-to-[1-13 C]lactate conversion.
Sign Up to like & getrecommendations! Published in 2023 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.29676
Abstract: PURPOSE To develop a high spatiotemporal resolution 3D dynamic pulse sequence for preclinical imaging of hyperpolarized [1-13 C]pyruvate-to-[1-13 C]lactate metabolism at 7T. METHODS A standard 3D balanced SSFP (bSSFP) sequence was modified to enable alternating-frequency… read more here.
Keywords: pyruvate lactate; bssfp; spatiotemporal resolution; lactate ... See more keywords
Association among plasma lactate, systemic inflammation, and mild cognitive impairment: a community-based study
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Sciences"
DOI: 10.1007/s10072-019-03900-9
Abstract: The level of lactate in the blood is associated with obesity, blood pressure, and type 2 diabetes. In addition, lactate is a pro-inflammatory cytokine, which plays an important role in the pathogenesis of cognitive impairment.… read more here.
Keywords: plasma lactate; lactate; association; cognitive impairment ... See more keywords
Hyperlactatemia in diabetic ketoacidosis is common and can be prolonged: lactate time-series from 25 intensive care admissions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Monitoring and Computing"
DOI: 10.1007/s10877-020-00532-9
Abstract: Hyperlactatemia is a documented complication of diabetic ketoacidosis (DKA). Lactate responses during DKA treatment have not been studied and were the focus of this investigation. Blood gas and electrolyte data from 25 DKA admissions to… read more here.
Keywords: dka; mmol; time series; lactate ... See more keywords