Association Between Early Lactate Levels and 30-Day Mortality in Clinically Suspected Sepsis in Children
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2016.3681
Abstract: Importance Improving emergency care of pediatric sepsis is a public health priority, but optimal early diagnostic approaches are unclear. Measurement of lactate levels is associated with improved outcomes in adult septic shock, but pediatric guidelines… read more here.
Keywords: lactate levels; sepsis; day mortality; lactate ... See more keywords
Biomimetic Nano‐Regulator that Induces Cuproptosis and Lactate‐Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400204
Abstract: Herein, a ccRCC targeting nanodrug is designed to enhance chemodynamic therapy (CDT) as well as activate cuproptosis and tumor immunotherapy via ccRCC cell membrane modifying CuO@Gd2O3 yolk‐like particles (CGYL) loaded with lactate oxidase (LOx) (mCGYL‐LOx).… read more here.
Keywords: ccrcc; mcgyl lox; cuproptosis; cell ... See more keywords
VaccineIntegrated Nanoplatform for Lactate‐Activatable Chemo/Chemodynamic Therapy and Multiple Immune Regulations of Tumor
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202502439
Abstract: Enhancing the synergistic effect of chemo‐immunotherapy remains a major challenge in the field of cancer treatment. Besides, the premature release of chemotherapeutic or immunotherapeutic agents usually causes systemic immune disorders, leading to the weakness of… read more here.
Keywords: multiple immune; regulations tumor; lactate activatable; tumor ... See more keywords
Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity
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DOI: 10.1002/advs.202204808
Abstract: Lactate, a characteristic metabolite of the tumor microenvironment (TME), drives immunosuppression and promotes tumor progression. Material‐engineered strategies for intratumoral lactate modulations demonstrate their promise for tumor immunotherapy. However, understanding of the inherent interconnections of material‐enabled… read more here.
Keywords: lactate depletion; intratumoral lactate; lactate; metabolic reprogramming ... See more keywords
Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression
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DOI: 10.1002/advs.202506214
Abstract: The “Warburg effect”, a hallmark of Osteosarcoma(OS), results in lactate accumulation due to aerobic glycolysis. The role and underlying mechanisms of lactate in OS are not well understood. Herein, the lactate‐activated hydroxycarboxylate receptor 1(HCAR1) is… read more here.
Keywords: osteosarcoma; progression; stat1 dephosphorylation; stat1 ... See more keywords
Whole‐cell Escherichia coli lactate biosensor for monitoring mammalian cell cultures during biopharmaceutical production
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26254
Abstract: Many high‐value added recombinant proteins, such as therapeutic glycoproteins, are produced using mammalian cell cultures. In order to optimize the productivity of these cultures it is important to monitor cellular metabolism, for example the utilization… read more here.
Keywords: whole cell; biosensor; mammalian cell; lactate ... See more keywords
Lactate Prevents Glucose Deprivation‐Induced Parthanatos in Gastric Cancer Cells Through Alleviating Intracellular Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70064
Abstract: Most evidence obtained to date suggests a pivotal role for lactate in the control of tumor growth and metastasis. However, the precise mechanism by which lactate decreases tumor cell death remains incompletely defined. Here, we… read more here.
Keywords: deprivation; induced parthanatos; gastric cancer; lactate ... See more keywords
Does a normal peripheral lactate value always indicate an aerobic tissue metabolism?
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.863
Abstract: Heart failure (HF) has been classically defined as a condition in which the heart is unable to deliver sufficient oxygen to match the needs of the metabolizing tissues. Dr Paul Wood was the first to… read more here.
Keywords: heart; lactate; heart failure; peripheral lactate ... See more keywords
On‐chip dielectrophoretic recovery and detection of a lactate sensing probiotic from model human saliva
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200214
Abstract: Early detection has led to increased survival for multiple cancers; however, the 5‐year survival rate of oral carcinoma (OC) has remained at 40% for the last several decades. Screening for OC is routinely done via… read more here.
Keywords: lactate; detection; chip dielectrophoretic; model ... See more keywords
Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30661
Abstract: It is unresolved why lactate is transported to the liver for further utilization within the physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) than liver. We point out that the answer… read more here.
Keywords: protons oxygen; cori cycle; warburg effect; lactate ... See more keywords
Lactate‐induced metabolic remodeling and myofiber type transitions via activation of the Ca2+‐NFATC1 signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31290
Abstract: Lactate can serve as both an energy substrate and a signaling molecule, exerting diverse effects on skeletal muscle physiology. Due to the apparently positive effects, it would be interesting to consider it as a sports… read more here.
Keywords: myofiber type; physiology; metabolic remodeling; ca2 ... See more keywords