Chemical inhibitors of hexokinase-2 enzyme reduce lactate accumulation, alter glycosylation processing, and produce altered glycoforms in CHO cell cultures.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28417
Abstract: Chinese hamster ovary (CHO) cells, predominant hosts for recombinant biotherapeutics production, generate lactate as a major glycolysis by-product. High lactate levels adversely impact cell growth and productivity. The goal of this study was to reduce… read more here.
Keywords: growth; cell; lactate accumulation; cho cell ... See more keywords
Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20170958
Abstract: The peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone (Rosi) appears to provide protection against organ dysfunction during endotoxaemia. We examined the potential benefits of Rosi on skeletal muscle protein maintenance and carbohydrate metabolism during lipopolysaccharide… read more here.
Keywords: muscle; muscle protein; lactate accumulation;
P790Verification of selective arterial blood sampling for the assessment of in-hospital mortality in acute decompensated heart failure
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0389
Abstract: Acidosis or lactate accumulation is frequently observed in patients with acute decompensated heart failure (ADHF). Although each value can be easily obtained and evaluated by arterial blood sampling, sampling to all patients is difficult in… read more here.
Keywords: lactate accumulation; blood sampling; blood; hospital mortality ... See more keywords
A Novel Approach to Determining the Alactic Time Span in Connection with Assessment of the Maximal Rate of Lactate Accumulation in Elite Track Cyclists.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of sports physiology and performance"
DOI: 10.1123/ijspp.2021-0464
Abstract: PURPOSE Following short-term all-out exercise, the maximal rate of glycolysis is frequently assessed on the basis of the maximal rate of lactate accumulation in the blood. Since the end of the interval without significant accumulation… read more here.
Keywords: talac; maximal rate; lactate accumulation; accumulation ... See more keywords