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Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000032485
Abstract: To investigate the impact of lactate metabolism genes, lactate metabolism-related genes (LMRG), and immune infiltrating cells on the prognosis of breast cancer. LMRG was identified via single-cell sequencing. Immune cell infiltration was obtained by the…
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Keywords:
metabolism;
lactate metabolism;
metabolism genes;
breast cancer ... See more keywords
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Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add3216
Abstract: Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse…
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Keywords:
essential early;
metabolism essential;
lactate metabolism;
early onset ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.801959
Abstract: Hepatocellular carcinoma (HCC) is the main subtype of primary liver cancer with high malignancy and poor prognosis. Metabolic reprogramming is a hallmark of cancer and has great importance on the tumor microenvironment (TME). As an…
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Keywords:
lactate metabolism;
microenvironment;
metabolism related;
hcc ... See more keywords
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Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.624607
Abstract: Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease continues to be a major global health challenge. Critical barriers, including but not limited to the development of multi-drug resistance, lack of diagnostic assays that…
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Keywords:
lactate metabolism;
metabolism;
infection;
tuberculosis ... See more keywords
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Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.829175
Abstract: Background Lung cancer has been a prominent research focus in recent years due to its role in cancer-related fatalities globally, with lung adenocarcinoma (LUAD) being the most prevalent histological form. Nonetheless, no signature of lactate…
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Keywords:
patients luad;
lactate metabolism;
lung adenocarcinoma;
signature ... See more keywords
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Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.934830
Abstract: Background: Lactate, an intermediate product of glycolysis, has become an essential regulator of tumor maintenance, development, and metastasis. Lactate can drive tumors by changing the microenvironment of tumor cells. Because of lactate’s important role in…
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Keywords:
lactate metabolism;
signature;
metabolism related;
tumor ... See more keywords
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Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949310
Abstract: Background: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to…
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Keywords:
metabolism;
luad patients;
lactate metabolism;
lung adenocarcinoma ... See more keywords
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Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02564
Abstract: Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells during inflammatory activation. Although immunomodulating effects of lactate have been reported, evidence from human studies is scarce. Here we…
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Keywords:
immune;
effects lactate;
lactate metabolism;
metabolism ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.881359
Abstract: Background Lactate metabolism is critically involved in the tumor microenvironment (TME), as well as cancer progression. It is important to note, however, that lactate metabolism-related long non-coding RNAs (laRlncRNAs) remain incredibly understudied in colon adenocarcinoma…
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Keywords:
lactate metabolism;
signature;
colon adenocarcinoma;
landscape ... See more keywords
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Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.998140
Abstract: Background Breast cancer is the most common cancer worldwide. Hypoxia and lactate metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia- and lactate metabolism-related gene signature to predict the survival, immune…
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Keywords:
lactate metabolism;
hypoxia lactate;
breast cancer;
risk ... See more keywords
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Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.1064349
Abstract: Background Glioma is one of the most typical tumors in the central nervous system with a poor prognosis, and the optimal management strategy remains controversial. Lactate in the tumor microenvironment is known to promote cancer…
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Keywords:
lactate metabolism;
prognosis;
signature;
risk ... See more keywords