Breast cancer combined prognostic model based on lactate metabolism genes
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DOI: 10.1097/md.0000000000032485
Abstract: To investigate the impact of lactate metabolism genes, lactate metabolism-related genes (LMRG), and immune infiltrating cells on the prognosis of breast cancer. LMRG was identified via single-cell sequencing. Immune cell infiltration was obtained by the… read more here.
Keywords: metabolism; lactate metabolism; metabolism genes; breast cancer ... See more keywords
Lactate metabolism is essential in early-onset mitochondrial myopathy
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DOI: 10.1126/sciadv.add3216
Abstract: Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse… read more here.
Keywords: essential early; metabolism essential; lactate metabolism; early onset ... See more keywords
A Novel Lactate Metabolism-Related Gene Signature for Predicting Clinical Outcome and Tumor Microenvironment in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.801959
Abstract: Hepatocellular carcinoma (HCC) is the main subtype of primary liver cancer with high malignancy and poor prognosis. Metabolic reprogramming is a hallmark of cancer and has great importance on the tumor microenvironment (TME). As an… read more here.
Keywords: lactate metabolism; microenvironment; metabolism related; hcc ... See more keywords
Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review
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DOI: 10.3389/fcimb.2021.624607
Abstract: Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease continues to be a major global health challenge. Critical barriers, including but not limited to the development of multi-drug resistance, lack of diagnostic assays that… read more here.
Keywords: lactate metabolism; metabolism; infection; tuberculosis ... See more keywords
Development and Validation of Lactate Metabolism-Related lncRNA Signature as a Prognostic Model for Lung Adenocarcinoma
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DOI: 10.3389/fendo.2022.829175
Abstract: Background Lung cancer has been a prominent research focus in recent years due to its role in cancer-related fatalities globally, with lung adenocarcinoma (LUAD) being the most prevalent histological form. Nonetheless, no signature of lactate… read more here.
Keywords: patients luad; lactate metabolism; lung adenocarcinoma; signature ... See more keywords
A novel lactate metabolism-related signature predicts prognosis and tumor immune microenvironment of breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.934830
Abstract: Background: Lactate, an intermediate product of glycolysis, has become an essential regulator of tumor maintenance, development, and metastasis. Lactate can drive tumors by changing the microenvironment of tumor cells. Because of lactate’s important role in… read more here.
Keywords: lactate metabolism; signature; metabolism related; tumor ... See more keywords
Identification of lactate metabolism-related subtypes and development of a lactate-related prognostic indicator of lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949310
Abstract: Background: Increasing evidence supports that lactate plays an important role in tumor proliferation, invasion and within the tumor microenvironment (TME). This is particularly relevant in lung adenocarcinoma (LUAD). Therefore, there is a current need to… read more here.
Keywords: metabolism; luad patients; lactate metabolism; lung adenocarcinoma ... See more keywords
In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes
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DOI: 10.3389/fimmu.2018.02564
Abstract: Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells during inflammatory activation. Although immunomodulating effects of lactate have been reported, evidence from human studies is scarce. Here we… read more here.
Keywords: immune; effects lactate; lactate metabolism; metabolism ... See more keywords
Lactate Metabolism-Associated lncRNA Pairs: A Prognostic Signature to Reveal the Immunological Landscape and Mediate Therapeutic Response in Patients With Colon Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.881359
Abstract: Background Lactate metabolism is critically involved in the tumor microenvironment (TME), as well as cancer progression. It is important to note, however, that lactate metabolism-related long non-coding RNAs (laRlncRNAs) remain incredibly understudied in colon adenocarcinoma… read more here.
Keywords: lactate metabolism; signature; colon adenocarcinoma; landscape ... See more keywords
A novel hypoxia- and lactate metabolism-related signature to predict prognosis and immunotherapy responses for breast cancer by integrating machine learning and bioinformatic analyses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.998140
Abstract: Background Breast cancer is the most common cancer worldwide. Hypoxia and lactate metabolism are hallmarks of cancer. This study aimed to construct a novel hypoxia- and lactate metabolism-related gene signature to predict the survival, immune… read more here.
Keywords: lactate metabolism; hypoxia lactate; breast cancer; risk ... See more keywords
Characterization of a lactate metabolism-related signature for evaluation of immune features and prediction prognosis in glioma
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DOI: 10.3389/fneur.2022.1064349
Abstract: Background Glioma is one of the most typical tumors in the central nervous system with a poor prognosis, and the optimal management strategy remains controversial. Lactate in the tumor microenvironment is known to promote cancer… read more here.
Keywords: lactate metabolism; prognosis; signature; risk ... See more keywords