Dynamic interactions in the l-lactate oxidase active site facilitate substrate binding at pH4.5.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.06.078
Abstract: The crystal structure of l-lactate oxidase in complex with l-lactate was solved at a 1.33 Å resolution. The electron density of the bound l-lactate was clearly shown and comparisons of the free form and substrate bound… read more here.
Keywords: lactate oxidase; substrate binding; active site; dynamic interactions ... See more keywords
High-performance, two-step/Bi-enzyme lactate biofuel cell with lactate oxidase and pyruvate oxidase
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Power Sources"
DOI: 10.1016/j.jpowsour.2021.229935
Abstract: Abstract The performance of biofuel cells (BFCs) depends on the number of electrons that can be harvested from one fuel molecule by the bioanode, as well as many other factors. Regular, one-enzyme bioanodes can usually… read more here.
Keywords: two step; performance; oxidase; lactate oxidase ... See more keywords
Repolarization of M2 to M1 macrophages triggered by lactate oxidase released from methylcellulose hydrogel.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00618
Abstract: Deregulated proliferation of tumor is generally associated with altered energy metabolism. A high rate of anaerobic glycolysis in solid tumors contributes to an acidification of pH to ~6.7-7.2 in the tumor microenvironment and lactate accumulation.… read more here.
Keywords: lactate oxidase; tumor microenvironment; repolarization; tumor ... See more keywords
Nitrogen-Centered Lactate Oxidase Nanozyme for Tumor Lactate Modulation and Microenvironment Remodeling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c02005
Abstract: Designing nanozymes that match natural enzymes have always been an attractive and challenging goal. In general, researchers mainly focus on the construction of metal centers and the control of non-metallic ligands of nanozyme to regulate… read more here.
Keywords: microenvironment; lactate oxidase; lactate; nitrogen centered ... See more keywords
Improved reuse and storage performances at room temperature of a new environmental-friendly lactate oxidase biosensor made by ambient electrospray immobilization
Sign Up to like & getrecommendations! Published in 2023 at "Green Chemistry"
DOI: 10.1039/d3gc00494e
Abstract: A new, environmental-friendly, lactate oxidase (LOX) based biosensor for lactate detection, with unprecedented reuse and storage capabilities at room temperature, has been manufactured using the ambient electrospray deposition (ESD) technique.... read more here.
Keywords: lactate oxidase; environmental friendly; new environmental; friendly lactate ... See more keywords
FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS ONE"
DOI: 10.2210/pdb6rht/pdb
Abstract: Lactate oxidases belong to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Hydrogen peroxide is also utilized as a read out in biosensors… read more here.
Keywords: pediococcus acidilactici; lactate oxidase; lactate; fmn dependent ... See more keywords
Biosensor Based on Peroxidase-Mimetic Nanozyme and Lactate Oxidase for Accurate L-Lactate Analysis in Beverages
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12111042
Abstract: Precision analysis of the key biological metabolites such as L-lactate has great practical importance for many technological processes in food technology, including beverage production. Here we describe a new, highly selective, and sensitive biosensor for… read more here.
Keywords: lactate oxidase; lactate; accurate lactate; analysis ... See more keywords