Metabolic engineering of Methanosarcina acetivorans for lactate production from methane
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26208
Abstract: We previously demonstrated anaerobic conversion of the greenhouse gas methane into acetate using an engineered archaeon that produces methyl‐coenzyme M reductase (Mcr) from unculturable microorganisms from a microbial mat in the Black Sea to create… read more here.
Keywords: methane; metabolic engineering; lactate production;
Resource allocation explains lactic acid production in mixed‐culture anaerobic fermentations
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27605
Abstract: Lactate production in anaerobic carbohydrate fermentations with mixed cultures of microorganisms is generally observed only in very specific conditions: the reactor should be run discontinuously and peptides and B vitamins must be present in the… read more here.
Keywords: resource allocation; production; lactate production; culture ... See more keywords
Noradrenaline‐induced l‐lactate production requires d‐glucose entry and transit through the glycogen shunt in single‐cultured rat astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24783
Abstract: During cognitive efforts mediated by local neuronal networks, approximately 20% of additional energy is required; this is mediated by chemical messengers such as noradrenaline (NA). NA targets astroglial aerobic glycolysis, the hallmark of which is… read more here.
Keywords: transit glycogen; glycogen; lactate production; glycogen shunt ... See more keywords
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66059-w
Abstract: In solid tumors, hypoxia can trigger aberrant expression of transcription factors and genes, resulting in abnormal biological functions such as altered energetic pathways in cancer cells. Glucose metabolism is an important part of this phenomenon,… read more here.
Keywords: determine key; glycolysis; glycolysis pathway; key regulators ... See more keywords
Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05593-1
Abstract: Lactate production is an important clue for understanding metabolic and signal responses to exercise but its measurement is difficult. Therefore, this study aimed (1) to develop a method of calculating lactate production volume during exercise… read more here.
Keywords: production; lactate production; production volume; exercise ... See more keywords
Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/nox170
Abstract: Background Glioblastomas have been shown to rely on glycolysis as an energy source. However, recent evidence suggests that at least a subset of glioma cells with stem cell-like properties can thrive on oxidative phosphorylation. It… read more here.
Keywords: glioma stem; production; glioma; lactate production ... See more keywords
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001304
Abstract: A hypoxic tumor microenvironment (TME) promotes cancer progression, yet its value as a therapeutic target remains underexploited. Tripartite motif-containing 72 (TRIM72) may protect cells against various stresses including hypoxia. Recently, low TRIM72 expression has been… read more here.
Keywords: lactate production; trim72; breast cancer; promoter activity ... See more keywords
Over-expression of an electron transport protein OmcS provides sufficient NADH for d-lactate production in cyanobacterium
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-021-01956-4
Abstract: Background An efficient supply of reducing equivalent is essential for chemicals production by engineered microbes. In phototrophic microbes, the NADPH generated from photosynthesis is the dominant form of reducing equivalent. However, most dehydrogenases prefer to… read more here.
Keywords: nadh lactate; production; sufficient nadh; electron transport ... See more keywords
Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011371
Abstract: Senecavirus A (SVA)-induced porcine idiopathic vesicular disease has caused huge economic losses worldwide. Glucose metabolism in the host cell is essential for SVA proliferation; however, the impact of the virus on glucose metabolism in host… read more here.
Keywords: lactate production; replication; glycolysis; sva ... See more keywords
An experimental and in silico analysis of Lacticaseibacillus paracasei isolated from whey shows an association between lactate production and amino acid catabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202220211071
Abstract: The production of lactic acid from agroindustry waste products, such as whey, heavily relies on microorganisms within the genusLactobacillus. In this work, a genome-scale metabolic model was implemented from Vinay-Lara (iLca334_548), improved adding some enzymatic… read more here.
Keywords: lactate production; acid catabolism; lactic acid; production ... See more keywords
Lactate Dehydrogenase A or B Knockdown Reduces Lactate Production and Inhibits Breast Cancer Cell Motility in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.747001
Abstract: Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis and enhanced expression/activity of this enzyme has been correlated with poor prognosis. In this study we determined the expression profile of LDH-A and B… read more here.
Keywords: cell motility; lactate production; breast cancer; cancer ... See more keywords