The Science and Translation of Lactate Shuttle Theory.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.03.008
Abstract: Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Shuttling between producer and consumer cells fulfills at least three purposes for lactate: (1) a… read more here.
Keywords: medicine; lactate shuttle; lactate; shuttle theory ... See more keywords
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Sport and Health Science"
DOI: 10.1016/j.jshs.2020.02.006
Abstract: Highlights • In the 2019 American College of Sports Medicine Wolffe lecture George Brooks described history Lactate Shuttle development.• Lactate is a fuel energy source, the main gluconeogenic precursor, and a signaling molecule with autocrine,… read more here.
Keywords: discovery cinders; lactate; path lactate; lactate shuttle ... See more keywords
Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21
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DOI: 10.7150/thno.44370
Abstract: A viewpoint considering Alzheimer's disease (AD) as “type 3 diabetes” emphasizes the pivotal role of dysfunctional brain energy metabolism in AD. The hormone fibroblast growth factor 21 (FGF21) is a crucial regulator in energy metabolism;… read more here.
Keywords: system; astrocyte neuron; neuron lactate; lactate shuttle ... See more keywords