Lactic acid induces lactate transport and glycolysis/OXPHOS interconversion in glioblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.092
Abstract: The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse… read more here.
Keywords: tumor; lactate transport; glioblastoma; lactic acid ... See more keywords
Involvement of monocarboxylate transporter 1 (SLC16A1) in the uptake of L‐lactate in human astrocytes☆
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.10.022
Abstract: Purpose: Astrocytes, the most abundant glial cells in the central nervous system (CNS), help neurons survive. Monocarboxylate transporters (MCTs) are reported to transport L‐lactate, which is important for CNS physiology and cognitive function. However, it… read more here.
Keywords: lactate transport; uptake lactate; lactate; human astrocytes ... See more keywords
An unexpected world population variation of MCT1 polymorphism 1470T > A involved in lactate transport
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Sport Science"
DOI: 10.1080/17461391.2018.1491629
Abstract: ABSTRACT A common missense mutation (1470T > A) in gene SLC16A1 responsible for an amino acid substitution in protein MCT1 has been associated with differential lactate transport and hence, differences in physical performance and muscle… read more here.
Keywords: variation mct1; population; lactate transport; world ... See more keywords
The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25371
Abstract: Highly glycolytic tumor cells release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbate extracellular acidification and support the formation of a hostile environment. Transport activity of MCTs can be facilitated by… read more here.
Keywords: lactate transport; transport; facilitation; cancer cells ... See more keywords
Monocarboxylate Transporter 1 May Benefit Cerebral Ischemia via Facilitating Lactate Transport From Glial Cells to Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.781063
Abstract: Monocarboxylate transporter 1 (MCT1) is expressed in glial cells and some populations of neurons. MCT1 facilitates astrocytes or oligodendrocytes (OLs) in the energy supplement of neurons, which is crucial for maintaining the neuronal activity and… read more here.
Keywords: lactate transport; cerebral ischemia; transport glial; glial cells ... See more keywords
Combining metformin with lactate transport inhibitors as a treatment modality for cancer - recommendation proposal
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1034397
Abstract: Highly glycolytic cancer cells excrete lactate to maintain cellular homeostasis. Inhibiting lactate export by pharmacological targeting of plasma membrane lactate transporters is being pursued as an anti-cancer therapy. Work from many laboratories show that the… read more here.
Keywords: lactate transport; transport inhibitors; cancer; combining metformin ... See more keywords