Introduction of scaffold nitrogen atoms renders inhibitors of the malarial L-lactate transporter, PfFNT, effective against the Gly107Ser resistance mutation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00852
Abstract: The spreading of malaria parasites, Plasmodium falciparum, with resistance to all known drugs calls for novel classes of inhibitors with new modes of action. Recently, we discovered and validated the plasmodial L-lactate transporter, PfFNT, as… read more here.
Keywords: transporter pffnt; gly107ser; pffnt; lactate transporter ... See more keywords
Identifying the major lactate transporter of Toxoplasma gondii tachyzoites
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DOI: 10.1038/s41598-021-86204-3
Abstract: Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites and has been validated… read more here.
Keywords: lactate; lactate transporter; toxoplasma gondii; major lactate ... See more keywords