PINK1 siRNA‐loaded poly(lactic‐co‐glycolic acid) nanoparticles provide neuroprotection in a mouse model of photothrombosis‐induced ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24339
Abstract: PTEN‐induced kinase 1 (PINK1) is a well‐known critical marker in the pathway for mitophagy regulation as well as mitochondrial dysfunction. Evidence suggests that mitochondrial dynamics and mitophagy flux play an important role in the development… read more here.
Keywords: ischemic stroke; poly lactic; lactic glycolic; pink1 ... See more keywords
Preparation of Poly(lactic-co-glycolic acid)-Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800206
Abstract: In this work, a novel kind of electrospun microfiber to deliver a photothermal agent and an anticancer drug to tumor sites is explored. Photothermal therapy agent (MoS2 nanosheets) and doxorubicin (DOX) are incorporated with poly(lactic-co-glycolic… read more here.
Keywords: composite microfibers; poly lactic; lactic glycolic; nir biowindows ... See more keywords
Poly(lactic-co-glycolic acid) devices: Production and applications for sustained protein delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1516
Abstract: Injectable or implantable poly(lactic-co-glycolic acid) (PLGA) devices for the sustained delivery of proteins have been widely studied and utilized to overcome the necessity of repeated administrations for therapeutic proteins due to poor pharmacokinetic profiles of… read more here.
Keywords: poly lactic; production; delivery; biology ... See more keywords
Long acting injectable formulations: the state of the arts and challenges of poly(lactic-co-glycolic acid) microsphere, hydrogel, organogel and liquid crystal
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-019-00449-9
Abstract: BackgroundLong-acting injectable formulations (LAIFs) have received substantial attention recently due to their advantages over conventional formulations, including easy administration, continuous and controlled release of drug over months, and the ability to maintain drug concentrations within… read more here.
Keywords: poly lactic; injectable formulations; drug; lactic glycolic ... See more keywords
Comparative molecular dynamic simulation study on the use of chitosan for temperature stabilization of interferon αII.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.09.032
Abstract: Carbohydrate biopolymer of biocompatible biodegradable chitosan, currently become one of the most usable polymer in medical and pharmaceutical sciences. In this regard a large number of protein and peptide drugs are used as therapeutic agents… read more here.
Keywords: protein; poly lactic; temperature; interferon ... See more keywords
Ciprofloxacin‐loaded sodium alginate/poly (lactic‐co‐glycolic acid) electrospun fibrous mats for wound healing
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.11.004
Abstract: Graphical abstract Figure. No Caption available. Abstract Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to… read more here.
Keywords: poly lactic; ciprofloxacin; sodium alginate; lactic glycolic ... See more keywords
Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1.
Sign Up to like & getrecommendations! Published in 2020 at "European polymer journal"
DOI: 10.1016/j.eurpolymj.2020.109598
Abstract: Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we… read more here.
Keywords: poly lactic; jnk; novel jnk; jnk inhibitor ... See more keywords
pH-responsive Astragalus polysaccharides-loaded poly(lactic-co-glycolic acid) nanoparticles and their in vitro immunogenicity.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.12.156
Abstract: Astragalus polysaccharides (APS) have long been well known as immune boosters, but have not been fully exploited in clinical settings. Here, poly(lactic-co-glycolic acid) (PLGA) was used to form a nanocarrier for APS to enhance its… read more here.
Keywords: poly lactic; astragalus polysaccharides; responsive apsps; lactic glycolic ... See more keywords
Enhanced cell viability in hyaluronic acid coated poly(lactic-co-glycolic acid) porous scaffolds within microfluidic channels.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.09.053
Abstract: The concept of the present work is to produce porous optimised scaffolds of poly(lactic-co-glycolic acid) (PLGA) coated with hyaluronic acid (HA), to provide a suitable microenvironment for cellular proliferation. Freeze dried scaffolds were produced from… read more here.
Keywords: poly lactic; within microfluidic; hyaluronic acid; lactic glycolic ... See more keywords
The mechanism behind the biphasic pulsatile drug release from physically mixed poly(dl‐lactic(‐co‐glycolic) acid)‐based compacts
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.025
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Successful immunization often requires a primer, and after a certain lag time, a booster administration of the antigen. To improve the vaccinees’ comfort and compliance, a single‐injection vaccine… read more here.
Keywords: poly lactic; mechanism; drug; biphasic pulsatile ... See more keywords
Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2019.08.006
Abstract: HYPOTHESIS The widespread resistance of bacteria to traditional antibiotic treatments has expedited the search for novel therapies against these pathogens. The hypothesis of this work is that two distinctively different polymeric delivery systems, specifically D-α-tocopherol… read more here.
Keywords: poly lactic; biofilm; hyaluronic acid; lactic glycolic ... See more keywords