Reversion of Multidrug Resistance by Co-Encapsulation of Doxorubicin and Metformin in Poly(lactide-co-glycolide)-d-α-tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2404-7
Abstract: PurposeP-glycoprotein (P-gp) mediated multidrug resistance (MDR) has been recognized as the main obstacle against successful cancer treatment. To address this problem, co-encapsulated doxorubicin (DOX) and metformin (Met) in a biodegradable polymer composed of poly(lactide-co-glycolide) (PLGA)… read more here.
Keywords: tocopheryl polyethylene; poly lactide; lactide glycolide; dox ... See more keywords
Regorafenib-loaded poly (lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2020.01.001
Abstract: Transarterial chemoembolization (TACE) has been widely introduced to treat hepatocellular carcinoma (HCC) especially for unresectable patients for decades. However, TACE evokes an angiogenic response due to the secretion of vascular endothelial growth factor (VEGF), resulting… read more here.
Keywords: hepatocellular carcinoma; loaded poly; rego; poly lactide ... See more keywords
Chitosan/carboxymethylcellulose-stabilized poly(lactide-co-glycolide) particles as bio-based drug delivery carriers.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116417
Abstract: Poly(lactide-co-glycolide) (PLGA) colloidal particles stabilized by complexes of two oppositely charged polysaccharides, chitosan (cationic, CS) and sodium carboxymethylcellulose (anionic, NaCMC), were fabricated. Dichloromethane containing dissolved PLGA was first emulsified in an aqueous phase containing mixtures… read more here.
Keywords: poly lactide; lactide glycolide; plga particles; covered plga ... See more keywords
Synthesis, self-assembly and thermoresponsive behavior of Poly(lactide-co-glycolide)-b-Poly(ethylene glycol)-b-Poly(lactide-co-glycolide) copolymer in aqueous solution
Sign Up to like & getrecommendations! Published in 2021 at "Polymer"
DOI: 10.1016/j.polymer.2021.123673
Abstract: Abstract Thermoresponsive block copolymer (BCP) micelles have attracted increasing attentions due to their potential in biological applications. Many studies have investigated facile strategies to tune the cloud point (Tcp) of thermoresponsive polymer, such as changing… read more here.
Keywords: lactide glycolide; plga; copolymer; poly lactide ... See more keywords
Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01829
Abstract: Due to their excellent in vitro activity against multidrug resistant bacteria, antimicrobial peptides (AMPs) hold promise for treatment of Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) sufferers. In this work, poly(lactide- co-glycolide) (PLGA) nanoparticles… read more here.
Keywords: pseudomonas aeruginosa; poly lactide; lactide glycolide; aeruginosa lung ... See more keywords
Calcium-Binding Polymer-Coated Poly(lactide- co-glycolide) Microparticles for Sustained Release of Quorum Sensing Inhibitors to Prevent Biofilm Formation on Hydroxyapatite Surfaces.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b18301
Abstract: Quorum sensing (QS) inhibitor-based therapy is an attractive strategy to inhibit bacterial biofilm formation without excessive induction of antibiotic resistance. Thus, we designed Ca2+-binding poly(lactide- co-glycolide) (PLGA) microparticles that can maintain a sufficient concentration of… read more here.
Keywords: hydroxyapatite surfaces; poly lactide; biofilm formation; lactide glycolide ... See more keywords
Synthesis, characterization, and degradation behaviors of poly(D,L-lactide-co-glycolide) modified by maleic anhydride and ethanediamine
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Polymer Analysis and Characterization"
DOI: 10.1080/1023666x.2017.1344819
Abstract: ABSTRACT In order to improve hydrophilicity and settle the acidity in hydrolysis, a novel ethanediamine (EDA) and maleic anhydride (MAH) modified poly(D,L-lactide-co-glycolide) (PLGA) polymer (EMPLGA) was synthesized. Fourier Transform Infrared Spectrometer (FTIR), Gel Permeation Chromatography… read more here.
Keywords: maleic anhydride; degradation; poly lactide; degradation behaviors ... See more keywords
Fabrication of a reticular poly(lactide-co-glycolide) cylindrical scaffold for the in vitro development of microvascular networks
Sign Up to like & getrecommendations! Published in 2017 at "Science and Technology of Advanced Materials"
DOI: 10.1080/14686996.2016.1278351
Abstract: Abstract The microvascular network is a simple but critical system that is responsible for a range of important biological mechanisms in the bodies of all animals. The ability to generate a functional microvessel not only… read more here.
Keywords: poly lactide; lactide glycolide; fabrication reticular; cylindrical scaffold ... See more keywords
Determination of Electrospinning Parameters’ Strength in Poly(D,L)-lactide-co-glycolide Micro/Nanofiber Diameter Tailoring
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nanomaterials"
DOI: 10.1155/2019/2626085
Abstract: Electrospinning has received increasing interest and attention in recent years for fabricating micro/nanofibers of various materials; this is due to its versatility and capability of multiple field applications, including filtration, biosensors, tissue engineering, wound dressings,… read more here.
Keywords: poly lactide; micro; diameter; lactide glycolide ... See more keywords
Preparation of osteoinductive – Antimicrobial nanocomposite scaffolds based on poly (D,L-lactide-co-glycolide) modified with copper – Doped bioactive glass nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Polymers and Polymer Composites"
DOI: 10.1177/09673911221098231
Abstract: The aim of this study was to explore the preparation of porous nanocomposite scaffolds with simultaneous osteogenic – antibacterial properties by incorporating copper – doped bioactive glass nanoparticles into Poly (D,L-lactide-co-glycolide) lactide:glycolide. Bioactive glass nanoparticles… read more here.
Keywords: copper; bioactive glass; lactide glycolide; nanocomposite scaffolds ... See more keywords
Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects—In Vivo Studies on Rabbits
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21207541
Abstract: Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent… read more here.
Keywords: hap; poly lactide; tissue; lactide glycolide ... See more keywords