Enzymatic Hydrolysis of Human Milk Oligosaccharides. The Molecular Mechanism of Bifidobacterium Bifidum Lacto-N-biosidase
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DOI: 10.1021/acscatal.2c00309
Abstract: Bifidobacterium bifidum lacto-N-biosidase (LnbB) is a critical enzyme for the degradation of human milk oligosaccharides in the gut microbiota of breast-fed infants. Guided by recent crystal structures, we unveil its molecular mechanism of catalysis using… read more here.
Keywords: milk oligosaccharides; bifidobacterium bifidum; bifidum lacto; human milk ... See more keywords
Transglycosylation Activity of Engineered Bifidobacterium Lacto-N-Biosidase Mutants at Donor Subsites for Lacto-N-Tetraose Synthesis
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DOI: 10.3390/ijms22063230
Abstract: The health benefits of human milk oligosaccharides (HMOs) make them attractive targets as supplements for infant formula milks. However, HMO synthesis is still challenging and only two HMOs have been marketed. Engineering glycoside hydrolases into… read more here.
Keywords: lacto biosidase; transglycosylation activity; lacto tetraose; activity ... See more keywords