One-pot Synthesis of Depolymerizable δ-lactone Based Vitrimers.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202300954
Abstract: Here we report a depolymerizable vitrimer that allows both reprocessability and monomer recovering by a simple and scalable one-pot two-step synthesis of vitrimers from cyclic lactones. Biobased δ-valerolactone with alkyl substituents (δ-lactone) has low ceiling… read more here.
Keywords: pot synthesis; vitrimer; lactone; one pot ... See more keywords
Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800821
Abstract: Enzyme‐catalyzed β‐lactone formation from β‐hydroxy acids is a crucial step in bacterial biosynthesis of β‐lactone natural products and membrane hydrocarbons. We developed a novel, continuous assay for β‐lactone synthetase activity using synthetic β‐hydroxy acid substrates… read more here.
Keywords: standalone lactone; synthetase new; lactone; lactone synthetase ... See more keywords
Telomerization of 1,3‐Butadiene with Carbon Dioxide: A Highly Efficient Process for δ‐Lactone Generation
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201701058
Abstract: A very efficient and selective telomerization of 1,3‐butadiene with CO2 that leads to the δ‐lactone (3‐ethylidene‐6‐vinyltetrahydro‐2H‐pyran‐2‐one) was obtained using palladium acetate and tris(p‐methoxyphenyl)phosphine as a catalyst in the presence of p‐hydroquinone, N,N‐diisopropylethylamine, and acetonitrile. A… read more here.
Keywords: telomerization butadiene; lactone; butadiene carbon; telomerization ... See more keywords
Tandem Thio‐Michael Addition/Remote Lactone Activation of 5‐Hydroxymethylfurfural‐Derived δ‐Lactone‐Fused Cyclopentenones
Sign Up to like & getrecommendations! Published in 2022 at "Chemsuschem"
DOI: 10.1002/cssc.202102204
Abstract: Abstract The creation of structurally diverse chemical entities from fairly simple biorefinery products remains a challenge. In this work 5‐hydroxymethylfurfural (HMF) was identified as a key synthon for preparing highly complex cyclopentenones (CP) via tandem… read more here.
Keywords: addition; lactone fused; lactone; remote lactone ... See more keywords
Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl‐JAK/STAT Signaling Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25994
Abstract: This study evaluates the anticancer effects of dehydrocostus lactone, a plant‐derived sesquiterpene lactone, on human chronic myeloid leukemia cells. Dehydrocostus lactone significantly inhibits cell proliferation by inducing cells to undergo cell cycle arrest, apoptosis, and… read more here.
Keywords: lactone; myeloid leukemia; dehydrocostus lactone; chronic myeloid ... See more keywords
Syzysamalactone, an Unusual 11-Carbon δ-Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01114
Abstract: To study the chemical constituents from the ripe fresh fruits of Syzygium samarangense (wax apple) and their potential health effects, a phytochemical investigation was undertaken. A new δ-lactone derivative, syzysamalactone (1), along with a known… read more here.
Keywords: fruits syzygium; lactone; lactone derivative; samarangense wax ... See more keywords
Quantitative Map of β-Lactone-Induced Virulence Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00705
Abstract: β-Lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus… read more here.
Keywords: lactone; virulence; toxin; virulence regulation ... See more keywords
Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00477
Abstract: Camptothecins exist in a pH-dependent equilibrium between the active, closed lactone and the inactive open-carboxylate forms. Several previous reports underscore the need for lactone stabilization in generating improved camptothecins, and indeed, such designs have been… read more here.
Keywords: lactone; closed lactone; stabilization necessary; drug ... See more keywords
Stereoselective Total Synthesis of the Dimeric Naphthoquinonopyrano-γ-lactone (-)-Crisamicin A: Introducing the Dimerization Site by a Late-Stage Hartwig Borylation.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01078
Abstract: The first stereoselective total synthesis of the dimeric naphthoquinonopyrano-γ-lactone (-)-crisamicin A was realized (13 steps, 5% overall yield). 1,4,5-Trimethoxynaphthalene, reached in five known steps, was brominated at C-3 to install a but-3-enoic ester by an… read more here.
Keywords: synthesis dimeric; crisamicin; lactone; stereoselective total ... See more keywords
Closing the "One Monomer-Two Polymers-One Monomer" Loop via Orthogonal (De)polymerization of a Lactone/Olefin Hybrid.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12278
Abstract: Two well-known low-ceiling-temperature (LCT) monomers, γ-butyrolactone (γ-BL) toward ring-opening polymerization (ROP) to polyester and cyclohexene toward ring-opening metathesis polymerization (ROMP) to poly(cyclic olefin), are notoriously "nonpolymerizable". Here we present a strategy to render not only… read more here.
Keywords: rop; monomer; lactone; orthogonal polymerization ... See more keywords
Britannin a Sesquiterpene Lactone from Inula aucheriana Exerted an Anti-leukemic Effect in Acute Lymphoblastic Leukemia (ALL) Cells and Enhanced the Sensitivity of the Cells to Vincristine.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1931700
Abstract: Since chemotherapy drugs have dose-related side effects, there is still a need for finding new agents with suitable cytotoxic effects without any harmful effects. For this purpose, we evaluated the cytotoxic effects of Britannin that… read more here.
Keywords: cytotoxic effects; inula aucheriana; lactone; acute lymphoblastic ... See more keywords