Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800821
Abstract: Enzyme‐catalyzed β‐lactone formation from β‐hydroxy acids is a crucial step in bacterial biosynthesis of β‐lactone natural products and membrane hydrocarbons. We developed a novel, continuous assay for β‐lactone synthetase activity using synthetic β‐hydroxy acid substrates… read more here.
Keywords: standalone lactone; synthetase new; lactone; lactone synthetase ... See more keywords
β-Lactone Synthetase Found in the Olefin Biosynthesis Pathway.
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DOI: 10.1021/acs.biochem.6b01199
Abstract: The first β-lactone synthetase enzyme is reported, creating an unexpected link between the biosynthesis of olefinic hydrocarbons and highly functionalized natural products. The enzyme OleC, involved in the microbial biosynthesis of long-chain olefinic hydrocarbons, reacts… read more here.
Keywords: biosynthesis; synthetase found; lactone synthetase; found olefin ... See more keywords