Lactonization of Diols Over Highly Efficient Metal-Based Catalysts.
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DOI: 10.1002/cssc.202400909
Abstract: Lactones has gained increasing attention in recent years due to wide application in polymer and pharmaceutical industries. Traditional synthetic methods of lactones often involve harsh operating temperature, use of strong alkalis and toxic oxidants. Therefore,… read more here.
Keywords: efficient metal; diols highly; lactonization; lactonization diols ... See more keywords
Carboxylic Acid Directed γ-Lactonization of Unactivated Primary C–H Bonds Catalyzed by Mn Complexes: Application to Stereoselective Natural Product Diversification
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DOI: 10.1021/jacs.2c08620
Abstract: Reactions that enable selective functionalization of strong aliphatic C–H bonds open new synthetic paths to rapidly increase molecular complexity and expand chemical space. Particularly valuable are reactions where site-selectivity can be directed toward a specific… read more here.
Keywords: carboxylic acid; unactivated primary; lactonization; primary bonds ... See more keywords
Versatile Copper-Catalyzed γ-C(sp3)-H Lactonization of Aliphatic Acids.
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DOI: 10.1021/jacs.4c04043
Abstract: Site-selective C(sp3)-H oxidation is of great importance in organic synthesis and drug discovery. γ-C(sp3)-H lactonization of free carboxylic acids provides the most straightforward means to prepare biologically important lactone scaffolds from abundant and inexpensive carboxylic… read more here.
Keywords: sp3 lactonization; lactonization; carboxylic acids; aliphatic acids ... See more keywords
Enantioselective lactonization catalyzed by chiral N-heterocyclic carbenes enables access to inherently chiral eight-membered lactones
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DOI: 10.1039/d5sc05037e
Abstract: Chiral saddle-shaped molecules are an emerging class of compounds with significant potential in both materials science and medicinal chemistry. However, their broader application has been hindered by limited synthetic accessibility. Herein, we report a metal-free,… read more here.
Keywords: chiral heterocyclic; catalyzed chiral; lactonization; enantioselective lactonization ... See more keywords
Visible-Light-Induced Arene C(sp2)–H Lactonization Promoted by DDQ and tert-Butyl Nitrite
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DOI: 10.1055/s-0039-1691537
Abstract: A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp2)–H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert-butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding… read more here.
Keywords: ddq tert; arene sp2; visible light; tert butyl ... See more keywords
t BuO2H/Cu(acac)2-Mediated Intramolecular Oxidative Lactonization of o-Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans
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DOI: 10.1055/s-0040-1706469
Abstract: A concise route for the t BuO2H/Cu(acac)2-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o-allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is… read more here.
Keywords: synthesis; buo2h acac; lactonization; synthesis oxoisochromans ... See more keywords